Oxidant-Induced Activation of Protein Kinase C in Uc11mg Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Pharmacological Reviews

2024 • 2,716 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

1991 • 1,432 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Protein kinase C

1991 • 914 citations

たんぱく質‐色素結合の原理を用いるμg量のたんぱく質の定量のための迅速,高感度法

1976 • 752 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

The MARCKS family of cellular protein kinase C substrates.

1993 • 484 citations

Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain.

1989 • 409 citations

Protein kinase C, calcium and phospholipid degradation

1992 • 400 citations

Pharmacology of Protein Kinase Inhibitors

1992 • 367 citations

Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.

1985 • 361 citations

Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element.

1992 • 353 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Modulation of ion channel activity: a key function of the protein kinase C enzyme family.

1989 • 338 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Transcriptional activation of early‐response genes by hydrogen peroxide in a mouse osteoblastic cell line

1991 • 298 citations

Mechanism of c-fos induction by active oxygen.

1992 • 224 citations

Inositol lipids in cell signalling.

1989 • 212 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.

1986 • 193 citations

Free radicals and ischemic tissue injury

1990 • 187 citations

Role of [Ca ²⁺ ] _i in induction of c‐ fos , c‐ jun and c‐ myc mRNA in rat PTE after oxidative stress

1992 • 168 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

Protein kinase C activators block specific calcium and potassium current components in isolated hippocampal neurons

1988 • 160 citations

Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat

1990 • 154 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

Translocation and enhancement of phosphotransferase activity of protein kinase C following exposure in mouse epidermal cells to oxidants.

1989 • 132 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80,000 protein kinase C substrate in permeabilized 3T3 cells. Effect of guanine nucleotides.

1988 • 120 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Protein kinase C activity in the rat hippocampus after forebrain ischemia: autoradiographic analysis by [3H]phorbol 12,13-dibutyrate

1989 • 116 citations

Hydroperoxide-Induced Diacylglycerol Formation and Protein Kinase C Activation in Vascular Endothelial Cells

1993 • 109 citations

Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Characterization of a DNA-protein interaction at the antioxidant responsive element and induction by 12-O-tetradecanoylphorbol 13-acetate.

1993 • 100 citations

Protein kinase C is translocated to cell membranes during cerebral ischemia

1990 • 93 citations

Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart

1986 • 90 citations

Free radical mediation of the effects of acidosis on calcium transport by cardiac sarcoplasmic reticulum in whole heart homogenates

1984 • 89 citations

The AP-1 complex and its role in transcriptional control by protein kinase C

1991 • 87 citations

Activation of rat brain protein kinase C by lipid oxidation products

1988 • 83 citations

Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity.

1988 • 83 citations

Effect of Brain Ischemia on Protein Kinase C

1992 • 82 citations

Protein kinase C involvement in lipid peroxidation and cell membrane damage induced by oxygen-based radicals in hepatocytes

1989 • 77 citations

Oxidation-induced persistent activation of protein kinase C in hippocampal homogenates

1992 • 76 citations

Biochimica et Biophysica Acta, 1024 (1990) 61–81

1990 • 56 citations

Immunohistochemical distribution of protein kinase C isozymes is differentially altered in ischemic gerbil hippocampus

1992 • 43 citations

Altered protein kinase C activity in different subfields of hippocampus following cerebral ischemia

1990 • 24 citations

Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia

1991 • 23 citations

Electrophysiological and biochemical characterization of a continuous human astrocytoma cell line with many properties of well-differentiated astrocytes

1989 • 18 citations

Cardiovascular Research

2006 • 16 citations