Protein Kinase C–Dependent Increase in Reactive Oxygen Species (ROS) Production in Vascular Tissues of Diabetes

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy

2000 • 3,103 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators.

2000 • 2,085 citations

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

2000 • 1,537 citations

Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus

2001 • 1,192 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications

2002 • 1,000 citations

Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus

2002 • 970 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation.

1997 • 756 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes

1990 • 696 citations

Increased NADH-Oxidase–Mediated Superoxide Production in the Early Stages of Atherosclerosis

1999 • 689 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Improvement of Nitric Oxide–Dependent Vasodilatation by HMG-CoA Reductase Inhibitors Through Attenuation of Endothelial Superoxide Anion Formation

2000 • 520 citations

p47phox is required for atherosclerotic lesion progression in ApoE–/– mice

2001 • 478 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: Effects of ACEI and ARB

2002 • 372 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Expression of NADH/NADPH Oxidase p22 ^phox in Human Coronary Arteries

1999 • 259 citations

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

2003 • 254 citations

Oxidative DNA damage in diabetes mellitus: its association with diabetic complications

1999 • 207 citations

Accumulation of 8-Hydroxy-2′-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats

2002 • 199 citations

Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes

1998 • 196 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

1994 • 186 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Withdrawal of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Elicits Oxidative Stress and Induces Endothelial Dysfunction in Mice

2002 • 165 citations

Reduction of Albumin Excretion Rate in Normotensive Microalbuminuric Type 2 Diabetic Patients During Long-Term Simvastatin Treatment

1997 • 162 citations

Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes

2002 • 157 citations

Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/WOR diabetic rat

2000 • 153 citations

DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria

1994 • 120 citations

ESR measurement of free radicals in whole mice

1990 • 110 citations

High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.

1998 • 100 citations

Principles of the Metabolism of Nitroxides and Their Implications for Spin Trapping

1990 • 93 citations

Reversibility of the effects on local circulation of high lipid concentrations in blood

1990 • 55 citations

In Vivo Electron Paramagnetic Resonance Studies on Oxidative Stress Caused by X-Irradiation in Whole Mice

1997 • 54 citations

Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells

2001 • 53 citations

Novel insight into current models of NADPH oxidase regulation, assembly and localization in human polymorphonuclear leukocytes.

1999 • 32 citations

Effect of Eicosapentaenoic Acid on Glucose-Induced Diacylglycerol Synthesis in Cultured Bovine Aortic Endothelial Cells

1998 • 22 citations

Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase C activity in cultured aortic smooth muscle cells

2003 • 6 citations

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