Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Calcium signaling

1995 • 1,905 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Regulation of protein kinase C

1997 • 919 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

How photons start vision.

1996 • 326 citations

Diacylglycerols and phosphatidates: which molecular species are intracellular messengers?

1998 • 289 citations

Type I Phosphatidylinositol-4-phosphate 5-Kinases

1998 • 280 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Two Distinct Raf Domains Mediate Interaction with Ras

1995 • 243 citations

The Role of Phosphatases in Inositol Signaling Reactions

1999 • 224 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Inositides and the nucleus and inositides in the nucleus

1993 • 209 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates

1996 • 205 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

The biology of vision of Drosophila.

1996 • 192 citations

Diacylglycerol kinase: a key modulator of signal transduction?

1990 • 189 citations

The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition.

1987 • 181 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Regulation of Phospholipid Biosynthesis in the Yeast Saccharomyces cerevisiae

1996 • 179 citations

Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ

1996 • 167 citations

Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

1996 • 163 citations

A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.

1996 • 155 citations

Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.

1993 • 155 citations

Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex

1998 • 147 citations

Phosphatidic acid modulates DNA synthesis, phospholipase C, and platelet-derived growth factor mRNAs in cultured mesangial cells. Role of protein kinase C.

1990 • 134 citations

Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons.

1993 • 133 citations

Direct Stimulation of Vav Guanine Nucleotide Exchange Activity for Ras by Phorbol Esters and Diglycerides

1994 • 132 citations

The fatty acid composition of phosphatidylinositol from thrombin-stimulated human platelets.

1981 • 125 citations

Purification, cDNA‐cloning and expression of human diacylglycerol kinase

1990 • 124 citations

Different effects of sphingosine, R59022 and anionic amphiphiles on two diacylglycerol kinase isozymes purified from porcine thymus cytosol

1989 • 123 citations

Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts.

1987 • 119 citations

Nuclear diacylglycerol is increased during cell proliferation in vivo

1993 • 119 citations

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

1996 • 118 citations

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

1994 • 113 citations

Cloning of a Novel Human Diacylglycerol Kinase (DGKθ) Containing Three Cysteine-rich Domains, a Proline-rich Region, and a Pleckstrin Homology Domain with an Overlapping Ras-associating Domain

1997 • 105 citations

Cloning and Characterization of a Glucocorticoid-induced Diacylglycerol Kinase

1996 • 98 citations

Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion.

1996 • 93 citations

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

1997 • 91 citations

Light-mediated breakdown of phosphatidylinositol-4,5-bisphosphate in isolated rod outer segments of frog photoreceptor

1985 • 90 citations

Escherichia coli Diacylglycerol Kinase Is an Evolutionarily Optimized Membrane Enzyme and Catalyzes Direct Phosphoryl Transfer

1997 • 87 citations

The Cloning and Characterization of a Novel Human Diacylglycerol Kinase, DGKι

1998 • 82 citations

EF-hand motifs of α, β and γ isoforms of diacylglycerol kinase bind calcium with different affinities and conformational changes

1997 • 77 citations

Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system.

1986 • 70 citations

Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-ε

1993 • 70 citations

Ceramide is a competitive inhibitor of diacylglycerol kinase in vitro and in intact human leukemia (HL-60) cells.

1992 • 69 citations

Diacylglycerol Kinase Defect in a Drosophila Retinal Degeneration Mutant rdgA

1989 • 68 citations

The C-terminal part of diacylglycerol kinase α lacking zinc fingers serves as a catalytic domain

1996 • 66 citations

Altered signal transduction in erbB-transformed cells. Implication of enhanced inositol phospholipid metabolism in erbB-induced transformation.

1987 • 62 citations

Immunolocalization of Drosophila eye‐specific diacylgylcerol kinase, rdgA , which is essential for the maintenance of the photoreceptor

1997 • 61 citations

Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid

1994 • 61 citations

τ91, an Essential Subunit of Yeast Transcription Factor IIIC, Cooperates with τ138 in DNA Binding

1998 • 61 citations

Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity

1994 • 60 citations

Molecular cloning of a cDNA encoding diacylglycerol kinase (DGK) in Arabidopsis thaliana

1996 • 57 citations

Diacylglycerol kinase in receptor-stimulated cells converts its substrate in a topologically restricted manner.

1994 • 57 citations

Alternative splicing of the human diacylglycerol kinase ζ gene in muscle

1997 • 55 citations

Immunolocalization ofDrosophila eye-specific diacylgylcerol kinase,rdgA, which is essential for the maintenance of the photoreceptor

1997 • 54 citations

Translocation of diacylglycerol kinase in response to chemotactic peptide and phorbol ester in neutrophils

1987 • 54 citations

Phosphorylation of diacylglycerol kinase in vitro by protein kinase C

1989 • 53 citations

Molecular cloning of a Drosophila diacylglycerol kinase gene that is expressed in the nervous system and muscle.

1992 • 50 citations

Phorbol ester-induced translocation of diacylglycerol kinase from the cytosol to the membrane in Swiss 3T3 fibroblasts

1989 • 50 citations

Signal Transmission in Exocrine Cells Is Associated with Rapid Activity Changes of Acyltransferases and Diacylglycerol Kinase Due to Reversible Protein Phosphorylation

1989 • 49 citations

Phosphatidylinositol synthesis and phosphorylation are enhanced by light in rat retinas.

1983 • 49 citations

Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation.

1997 • 45 citations

Arachidonoyl-diacylglycerol Kinase SPECIFIC IN VITRO INHIBITION BY POLYPHOSPHOINOSITIDES SUGGESTS A MECHANISM FOR REGULATION OF PHOSPHATIDYLINOSITOL BIOSYNTHESIS

1995 • 40 citations

Ras‐binding domains: predicting function versus folding

1997 • 39 citations

The diacylglycerol kinase inhibitor, R59022, enhances the superoxide generation from human neutrophils induced by stimulation of fMet-Leu-Phe, IgG and C3b receptors

1987 • 38 citations

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in rat retina

1997 • 36 citations

Disappearance of diacylglycerol kinase translocation in ras-transformed cells

1988 • 32 citations

Membrane-associated diacylglycerol kinase activity is increased by noradrenaline, but not by angiotensin II, in arterial smooth muscle

1994 • 27 citations

The cloning and developmental regulation of murine diacylglycerol kinase ζ

1998 • 26 citations

A Drosophila gene encoding a protein with similarity to diacylglycerol kinase is expressed in specific neurons

1993 • 21 citations

Phosphatidic acid and polyphosphoinositide metabolism in rod outer segments. Differential role of soluble and peripheral proteins

1992 • 21 citations

Contribution of Protein Kinase C to the Phosphorylation of Rhodopsin in Intact Retinas

1997 • 21 citations

Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022

1993 • 20 citations

Diacylglycerol Kinase Is Stimulated by Arachidonic Acid in Neural Membranes

1994 • 19 citations

Effects of free fatty acids and acyl‐coenzyme a on diacylglycerol kinase in rat brain

1989 • 10 citations

The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle

1989 • 3 citations