Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

Membrane Asymmetry

1977 • 965 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Transphosphatidylation by Phospholipase D

1967 • 563 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Metabolism of Molecular Species of Diacylglycerophospholipids

1978 • 331 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Plasma Total Lipid, Cholesterol, Triglycerides, Phospholipids and Free Fatty Acids in a Healthy Scandinavian Population

1961 • 304 citations

Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.

1985 • 304 citations

A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine.

1986 • 267 citations

The formation of phosphatidylglycerol and other phospholipids by the transferase activity of phospholipase D

1967 • 261 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Choline-linked Phosphoglycerides

1989 • 234 citations

Kinetic analysis of 1,2-diacylglycerol mass levels in cultured fibroblasts. Comparison of stimulation by alpha-thrombin and epidermal growth factor.

1988 • 207 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Fast atom bombardment and tandem mass spectrometry of phosphatidylserine and phosphatidylcholine

1986 • 179 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Molecular Species Analysis of 1,2-Diglycerides Stimulated by α-Thrombin in Cultured Fibroblasts

1989 • 161 citations

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

1984 • 152 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Ca^{2 +}‐mobilizing hormones elicit phosphatidylethanol accumulation via phospholipase D activation

1987 • 130 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Diacylglycerol metabolism in mast cells. Analysis of lipid metabolic pathways using molecular species analysis of intermediates.

1987 • 112 citations

Hormonal stimulation of diacylglycerol formation in hepatocytes.

1989 • 111 citations

Tumor promoter stimulation of phosphatidylcholine turnover in HeLa cells.

1982 • 98 citations

Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase

1983 • 92 citations

Phosphatidylethanol formation in human platelets: Evidence for thrombin-induced activation of phospholipase D

1988 • 88 citations

Phorbol esters stimulate the rapid release of choline from prelabelled cells

1981 • 83 citations

The fatty acid composition of phosphatidylinositol, phosphatidate and 1,2-diacylglycerol in stimulated human neutrophils

1984 • 80 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Vasopressin, phorbol diesters and serum elicit choline glycerophospholipid hydrolysis and diacylglycerol formation in nontransformed cells: transformed derivatives do not respond

1988 • 69 citations

12-O-Tetradecanoylphorbol-13-acetate activates the synthesis of phosphatidylethanol in animal cells exposed to ethanol

1987 • 50 citations

Mobilization of cellular choline by stimulation of muscarine receptors in isolated chicken heart and rat cortex in vivo.

1983 • 41 citations

A real receptor-operated calcium channel?

1988 • 40 citations

Effects of cholinergic stimulation on levels and fatty acid composition of diacylglycerols in mouse pancreas

1981 • 40 citations

Differential regulation of phosphatidylcholine biosynthesis by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol in NG108-15 neuroblastoma x glioma hybrid cells.

1987 • 39 citations

Molecular species analysis of arachidonate containing glycerophosphocholines by tandem mass spectrometry

1991 • 38 citations

THE METABOLIC TURNOVER OF MOLECULAR SPECIES OF PHOSPHATIDYLINOSITOL and ITS PRECURSOR PHOSPHATIDIC ACID IN GUINEA‐PIG CEREBRAL HEMISPHERES

1976 • 34 citations

Phospholipase D-catalyzed hydrolysis of phosphatidylcholine occurs with PO bond cleavage

1991 • 33 citations

Structural and Mixture Analysis of Glycerophosphoric Acid Derivatives by Fast Atom Bombardment. Tandem Mass Spectrometry

1988 • 28 citations

Carbachol stimulates a different phospholipid metabolism than nerve growth factor and basic fibroblast growth factor in PC12 cells.

1991 • 26 citations

Bis(monoacylglycero) phosphate from PC12 cells, a phospholipid that can comigrate with phosphatidic acid: molecular species analysis by fast atom bombardment mass spectrometry

1992 • 21 citations

Phospholipid substrate-specificity of the <scp>l</scp>-serine base-exchange enzyme in rat liver microsomal fraction

1984 • 21 citations

Calcium-dependent incorporation of choline into phosphatidylcholine (PC) by base-exchange in rat brain membranes occurs preferentially with phospholipid substrates containing docosahexaenoic acid (22 : 6(n—3))

1990 • 7 citations