Elevated plasma endothelin‐1 level in streptozotocin‐induced diabetic rats and responsiveness of the mesenteric arterial bed to endothelin‐1

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat

1965 • 630 citations

Elevated plasma endothelin in patients with diabetes mellitus

1990 • 492 citations

Cellular mechanism of action by a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 385 citations

An o-Toluidine Method for Body-Fluid Glucose Determination

1962 • 380 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Functional consequences of streptozotocin-induced diabetes mellitus, with particular reference to the cardiovascular system.

1992 • 323 citations

Endothelin-1 and Endothelin-3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit

1989 • 302 citations

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

1989 • 294 citations

Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat

1989 • 260 citations

Endothelium-Mediated Vascular Function in Insulin-Dependent Diabetes Mellitus

1995 • 220 citations

Binding and receptor down‐regulation of a novel vasoconstrictor endothelin in cultured rat vascular smooth muscle cells

1988 • 215 citations

Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anaesthetized, spontaneously hypertensive rats

1988 • 199 citations

Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells

1990 • 196 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Molecular Pharmacology and Pathophysiological Significance of Endothelin

1996 • 176 citations

Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats.

1989 • 118 citations

Effect of glucose and insulin on immunoreactive endothelin-1 release from cultured porcine aortic endothelial cells

1991 • 116 citations

Molecular and cellular biology of endothelin and its receptors

1996 • 110 citations

Production of endothelin-1 from the mesenteric arteries of streptozotocin-induced diabetic rats

1991 • 98 citations

The effects of endothelin‐1 and N^G‐nitro‐<scp>l</scp>‐arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin‐induced diabetes mellitus

1991 • 89 citations

Attenuated responses to endothelin‐1, KCl and CaCl₂, but not noradrenaline, of aortae from rats with streptozotocin‐induced diabetes mellitus

1991 • 82 citations

Plasma Endothelinlike Immunoreactivity Levels in IDDM Patients with Microalbuminuria

1992 • 82 citations

Simultaneous perfusion of rat isolated superior mesenteric arterial and venous beds: comparison of their vasoconstrictor and vasodilator responses to agonists

1990 • 80 citations

Molecular and cellular biology of endothelin and its receptors???Part I

1993 • 70 citations

Endothelin inhibits ex vivo platelet aggregation in the rabbit

1988 • 54 citations

Endothelium‐dependent vasodilator effects of platelet activating factor on rat resistance vessels

1989 • 50 citations

Characterization of receptors for endothelins in the perfused arterial and venous mesenteric vasculatures of the rat

1993 • 47 citations

Changes in endothelium-dependent relaxation and levels of cyclic nucleotides in the perfused mesenteric arterial bed from streptozotocin-induced diabetic rats

1993 • 37 citations

Altered microvascular reactivity to endothelin‐1, endothelin‐3 and N^G‐nitro‐L‐arginine methyl ester in streptozotocin‐induced diabetes mellitus

1992 • 36 citations

Effects of glucose, insulin or aldose reductase inhibition on responses to endothelin‐1 of aortic rings from streptozotocin‐induced diabetic rats

1992 • 30 citations

Streptozotocin‐induced diabetes reduces the density of [¹²⁵I]‐endothelin‐binding sites in rat cardiac membranes

1989 • 29 citations

A comparative study on the rat aorta and mesenteric arterial bed of the possible role of nitric oxide in the desensitization of the vasoconstrictor response to an α₁‐adrenoceptor agonist

1997 • 29 citations

Homologous desensitization of the effects of endothelin on rabbit aorta rings and on cultured rat aorta smooth muscle cells

1990 • 22 citations

DECREASED CONVERSION OF BIG ENDOTHELIN-1 TO ENDOTHELIN-1 IN PATIENTS WITH DIABETES MELLITUS

1991 • 21 citations

Effects of chronic diabetes on the responsiveness to endothelin-1 and other agents of rat atria and thoracic aorta

1994 • 19 citations

Simultaneous measurement of vasodilation and changes in cyclic nucleotides in the perfused mesenteric arterial bed of the rat

1993 • 17 citations

Decrease of Renal Endothelin 1 Content and Gene Expression in Diabetic Rats with Moderate Hyperglycemia

1995 • 17 citations

Changes in the responsiveness to endothelin-1 in isolated atria from diabetic rats

1994 • 14 citations