Long-Chain Acyl CoA Regulation of Protein Kinase C and Fatty Acid Potentiation of Glucose-Stimulated Insulin Secretion in Clonalβ -Cells¹

Regulation of protein kinase C

1997 • 919 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

1997 • 669 citations

Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

1996 • 466 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids.

1986 • 309 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

1989 • 259 citations

Are Metabolic Oscillations Responsible for Normal Oscillatory Insulin Secretion?

1997 • 195 citations

Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets.

1988 • 173 citations

More Direct Evidence for a Malonyl-CoA–Carnitine Palmitoyltransferase I Interaction as a Key Event in Pancreatic β-Cell Signaling

1994 • 172 citations

Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A

1991 • 163 citations

Distinct Effects of Fatty Acids on Translocation of γ- and ε-Subspecies of Protein Kinase C

1998 • 137 citations

Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate.

1992 • 112 citations

Long Chain Coenzyme A Esters Activate the Pore-forming Subunit (Kir6.2) of the ATP-regulated Potassium Channel

1998 • 108 citations

Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.

1993 • 106 citations

Extraction of tissue long-chain acyl-CoA esters and measurement by reverse-phase high-performance liquid chromatography

1985 • 103 citations

Stimulation by <scp>d</scp>-glucose of mitochondrial oxidative events in islet cells

1987 • 101 citations

Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA

1988 • 96 citations

The metabolism of lipids in mouse pancreatic islets. The biosynthesis of triacylglycerols and phospholipids

1975 • 95 citations

Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells.

1992 • 87 citations

Protein kinase C in beta-cells: expression of multiple isoforms and involvement in cholinergic stimulation of insulin secretion

1996 • 85 citations

The metabolism of lipids in mouse pancreatic islets. The oxidation of fatty acids and ketone bodies

1975 • 81 citations

Pancreatic islets synthesize phospholipids de novo from glucose via acyl-dihydroxyacetone phosphate

1985 • 76 citations

Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism

1986 • 72 citations

Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin

1992 • 62 citations

Palmitoyl‐CoA and the acyl‐CoA thioester of the carcinogenic peroxisome‐proliferator ciprofibrate potentiate diacylglycerol‐activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme

1990 • 53 citations

Perifusion of a Clonal Cell Line of Simian Virus 40-Transformed Beta Cells: Insulin Secretory Dynamics in Response to Glucose, 3-Isobutyl-1-Methylxanthine, and Potassium

1985 • 49 citations

Rapid Glucose-Dependent Increases in Phosphatidic Acid and Phosphoinositides in Rat Pancreatic Islets*

1986 • 44 citations

LIPID MEDIATORS AND PROTEIN KINASE C FOR INTRACELLULAR SIGNALLING

1995 • 40 citations

cis-Unsaturated fatty acids stimulate catecholamine secretion, tyrosine hydroxylase and protein kinase C in adrenal medullary cells

1989 • 34 citations

Enhanced de novo synthesis of phosphatidic acid and phosphatidylinositol in rat pancreatic islets exposed to nutrient or neurotransmitter stimuli

1984 • 33 citations

Atypical protein kinase C isozyme zeta mediates carbachol-stimulated insulin secretion in RINm5F cells.

1998 • 33 citations