Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS)

1996 • 2,163 citations

Microalbuminuria Predicts Clinical Proteinuria and Early Mortality in Maturity-Onset Diabetes

1984 • 1,939 citations

Predicting Diabetic Nephropathy in Insulin-Dependent Patients

1984 • 1,603 citations

Hyperglycemic Pseudohypoxia and Diabetic Complications

1993 • 1,025 citations

Glomerular hemodynamics in experimental diabetes mellitus

1981 • 785 citations

Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation.

1992 • 743 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia

1994 • 444 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

A Randomised Controlled Trial of Vitamin E in Patients with Coronary Disease: The Cambridge Heart Antioxidant Study (CHAOS)

1996 • 353 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Relationship of Microvascular Disease in Diabetes to Metabolic Control

1977 • 297 citations

Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy

1994 • 273 citations

High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures

1991 • 251 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Molecular Cloning of a Novel Human Diacylglycerol Kinase Highly Selective for Arachidonate-containing Substrates

1996 • 205 citations

Diacylglycerol kinase: a key modulator of signal transduction?

1990 • 189 citations

Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration.

1987 • 188 citations

Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues

1994 • 186 citations

Renal function in streptozotocin-diabetic rats

1981 • 178 citations

Role for Protein Kinase C in the Mediation of Increased Fibronectin Accumulation by Mesangial Cells Grown in High-Glucose Medium

1993 • 178 citations

Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.

1995 • 175 citations

Normalization of Diacylglycerol-Protein Kinase C Activation by Vitamin E in Aorta of Diabetic Rats and Cultured Rat Smooth Muscle Cells Exposed to Elevated Glucose Levels

1994 • 170 citations

Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ

1996 • 167 citations

Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

1996 • 163 citations

Taurine ameliorates chronic streptozocin-induced diabetic nephropathy in rats

1995 • 158 citations

Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway

1995 • 158 citations

Glucose-induced protein kinase C activity regulates arachidonic acid release and eicosanoid production by cultured glomerular mesangial cells.

1993 • 141 citations

Porcine 80-kDa diacylglycerol kinase is a calcium-binding and calcium/phospholipid-dependent enzyme and undergoes calcium-dependent translocation.

1991 • 131 citations

Safety of Antioxidant Vitamins

1996 • 130 citations

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.

1994 • 128 citations

Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain

1992 • 120 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells

1994 • 113 citations

Photometry of Inulin and Polyfructosan by Use of a Cysteine/ Tryptophan Reaction

1977 • 108 citations

Translocation of protein kinase C ? and ? in rat glomerular mesangial cells cultured under high glucose conditions

1994 • 107 citations

Membrane-stabilizing effect of vitamin E: Effect of α-tocopherol and its model compounds on fluidity of lecithin liposomes

1988 • 105 citations

Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations

1988 • 102 citations

The glomerular mesangium in diabetes mellitus

1993 • 78 citations

New solvent system for extraction of tocopherols from biological specimens for HPLC determination and the evaluation of 2, 2, 5, 7, 8-pentamethyl-6-chromanol as an internal standard

1987 • 61 citations

Glomerulopathy in Spontaneously Diabetic Rat: Impact of Glycemic Control

1987 • 51 citations

Hyperglycemia and microangiopathy. Direct regulation by glucose of microvascular cells.

1992 • 39 citations

Prevention of glomerular hyperfiltration in rats with streptozotocin-induced diabetes by an atrial natriuretic peptide receptor antagonist

1995 • 30 citations

Effects of glucose on receptor-mediated phosphoinositide hydrolysis and second messenger generation in rat glomerular mesangial cells.

1991 • 23 citations