H2O2-Induced Tyrosine Phosphorylation of Protein Kinase Cδ by a Mechanism Independent of Inhibition of Protein-Tyrosine Phosphatase in CHO and COS-7 Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The MAPK signaling cascade

1995 • 3,300 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

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Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

Oxygen radicals and signaling

1998 • 1,163 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Redox signaling: hydrogen peroxide as intracellular messenger

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Activation of protein kinase C by tyrosine phosphorylation in response to H ₂ O ₂

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[41] Use of vanadate as protein-phosphotyrosine phosphatase inhibitor

1991 • 583 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.

1990 • 246 citations

Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases.

1996 • 238 citations

Low Levels of Arsenic Trioxide Stimulate Proliferative Signals in Primary Vascular Cells without Activating Stress Effector Pathways

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Activation of the Epidermal Growth Factor Receptor Signal Transduction Pathway Stimulates Tyrosine Phosphorylation of Protein Kinase C δ

1996 • 187 citations

Tyrosine phosphorylation of protein kinase C-delta in response to its activation.

1994 • 169 citations

Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta.

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Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation

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Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells

1988 • 120 citations

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy,isolation, and characterization.

1993 • 89 citations

Development of a Rapid Approach to Identification of Tyrosine Phosphorylation Sites: Application to PKCδ Phosphorylated upon Activation of the High Affinity Receptor for IgE in Rat Basophilic Leukemia Cells

1995 • 76 citations

The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells

1992 • 75 citations

Tyrosine phosphorylation of a mitogen-activated protein kinase-like protein occurs at a late step in exocytosis. Studies with tyrosine phosphatase inhibitors and various secretagogues in rat RBL-2H3 cells.

1993 • 75 citations

Identification of Tyrosine 187 as a Protein Kinase C-δ Phosphorylation Site

1996 • 62 citations

Opposing Effects of Protein Kinase C δ and Protein Kinase B α on H2O2-Induced Apoptosis in CHO Cells

1999 • 44 citations

Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. II. Structure determination.

1993 • 38 citations

Phosphoregulatory Tyrosine of Xenopus Mitogen‐Activated Protein Kinase is out of the Reach of the Enzyme Catalytic Center After Autophosphorylation

1996 • 12 citations