Redox-dependent downregulation of Rho by Rac

Rho GTPases in cell biology

2002 • 4,662 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Rac Downregulates Rho Activity

1999 • 840 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

2000 • 638 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3

2000 • 501 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity

2001 • 431 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

1998 • 392 citations

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

1997 • 360 citations

Determination of GTP loading on Rho

2000 • 339 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells

2002 • 276 citations

c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation.

1995 • 256 citations

The Inactivation Mechanism of Low Molecular Weight Phosphotyrosine-protein Phosphatase by H2O2

1998 • 217 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

Two Vicinal Cysteines Confer a Peculiar Redox Regulation to Low Molecular Weight Protein Tyrosine Phosphatase in Response to Platelet-derived Growth Factor Receptor Stimulation

2001 • 190 citations

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

1998 • 187 citations

RhoA-Dependent Phosphorylation and Relocalization of ERM Proteins into Apical Membrane/Actin Protrusions in Fibroblasts

1998 • 183 citations

Redox Changes of Cultured Endothelial Cells and Actin Dynamics

2000 • 167 citations

Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes

1998 • 158 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

The effect of platelet-derived growth factor on morphology and motility of human glial cells

1983 • 148 citations

Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation

1999 • 148 citations

PDGF receptor as a specific in vivo target for low M_r phosphotyrosine protein phosphatase

1995 • 106 citations

Probing cellular protein targets of H₂O₂ with fluorescein‐conjugated iodoacetamide and antibodies to fluorescein

1998 • 98 citations

The Low M r Protein-tyrosine Phosphatase Is Involved in Rho-mediated Cytoskeleton Rearrangement after Integrin and Platelet-derived Growth Factor Stimulation

2000 • 95 citations