Biology of the p21-Activated Kinases

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase

1998 • 1,384 citations

Apoptosis Signaling

2000 • 1,290 citations

Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization

1998 • 1,263 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

1999 • 1,048 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Proteins of the ADF/Cofilin Family: Essential Regulators of Actin Dynamics

1999 • 1,004 citations

Filamins as integrators of cell mechanics and signalling

2001 • 987 citations

Paxillin and focal adhesion signalling

2000 • 765 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

PAK Kinases Are Directly Coupled to the PIX Family of Nucleotide Exchange Factors

1998 • 745 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading

1998 • 638 citations

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

2002 • 633 citations

The Ste20 group kinases as regulators of MAP kinase cascades

2001 • 606 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

2001 • 546 citations

Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

2000 • 515 citations

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

1999 • 491 citations

PAK3 mutation in nonsyndromic X-linked mental retardation

1998 • 472 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Rho GTPases and their effector proteins

2000 • 461 citations

Cell motility: can Rho GTPases and microtubules point the way?

2001 • 447 citations

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1998 • 435 citations

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1997 • 422 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Cellular Signaling

2000 • 415 citations

The oncoprotein 18/stathmin family of microtubule destabilizers

2002 • 414 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1998 • 381 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

p21-Activated kinases: three more join the Pak

2002 • 370 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

1995 • 357 citations

Structure–function relationships in HIV‐1 Nef

2001 • 356 citations

p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis

2000 • 356 citations

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

2001 • 354 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

Current molecular models for NADPH oxidase regulation by Rac GTPase

2002 • 335 citations

A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1

1998 • 325 citations

Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1

2002 • 316 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

A Role for P21-Activated Kinase in Endothelial Cell Migration

1999 • 295 citations

Regulation of Macropinocytosis by p21-activated Kinase-1

2000 • 293 citations

Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16

2001 • 293 citations

HIV-1 Nef associated PAK and PI3-Kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

2001 • 292 citations

β ₂ -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

1998 • 290 citations

Rho: theme and variations

1996 • 290 citations

Pak Functions Downstream of Dock to Regulate Photoreceptor Axon Guidance in Drosophila

1999 • 289 citations

Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase

1998 • 288 citations

Emerging from the Pak: the p21-activated protein kinase family

1997 • 285 citations

Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation

2000 • 276 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

p21-activated Kinase Links Rac/Cdc42 Signaling to Merlin

2002 • 271 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin

2001 • 265 citations

Requirement for PAK4 in the Anchorage-independent Growth of Human Cancer Cell Lines

2002 • 262 citations

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck

1997 • 259 citations

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization

2002 • 255 citations

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

2000 • 248 citations

Identification of a Central Phosphorylation Site in p21-activated Kinase Regulating Autoinhibition and Kinase Activity

1999 • 245 citations

The Mechanism of PAK Activation

2001 • 243 citations

How BAD phosphorylation is good for survival

1999 • 242 citations

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

2000 • 238 citations

p21-activated Kinase (PAK1) Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Kinase-1 (PDK1)

2000 • 235 citations

The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals

2000 • 235 citations

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1997 • 234 citations

Pak1 Kinase Homodimers Are Autoinhibited in trans and Dissociated upon Activation by Cdc42 and Rac1

2002 • 232 citations

Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells

1997 • 230 citations

14-3-3 Regulates Actin Dynamics by Stabilizing Phosphorylated Cofilin

2002 • 227 citations

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

2000 • 225 citations

Growth Factors Inactivate the Cell Death Promoter BAD by Phosphorylation of Its BH3 Domain on Ser155

2000 • 225 citations

Direct Involvement of Yeast Type I Myosins in Cdc42-Dependent Actin Polymerization

2000 • 223 citations

Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases

1998 • 223 citations

Pheromone signalling and polarized morphogenesis in yeast

1997 • 221 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

1999 • 214 citations

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

2001 • 214 citations

Shear Stress-Mediated Cytoskeletal Remodeling and Cortactin Translocation in Pulmonary Endothelial Cells

2002 • 212 citations

PAK promotes morphological changes by acting upstream of Rac

1998 • 211 citations

Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase

2000 • 210 citations

A GTPase-independent Mechanism of p21-activated Kinase Activation

1998 • 204 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation

1998 • 201 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts

1997 • 199 citations

GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration

2002 • 197 citations

Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p

1997 • 193 citations

The p21Rac/Cdc42-activated kinases (PAKs)

1998 • 190 citations

Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

1997 • 188 citations

Stimulation of NFκB Activity by Multiple Signaling Pathways Requires PAK1

2000 • 188 citations

Promoter Selectivity of Escherichia coli RNA Polymerase Eσ70 and Eσ38 Holoenzymes

1996 • 186 citations

P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium

2002 • 184 citations

Structure of Cdc42 bound to the GTPase binding domain of PAK.

2000 • 180 citations

Ligands of Macrophage Scavenger Receptor Induce Cytokine Expression via Differential Modulation of Protein Kinase Signaling Pathways

2001 • 170 citations

Regulation of Microfilament Reorganization and Invasiveness of Breast Cancer Cells by Kinase Dead p21-activated Kinase-1

2000 • 167 citations

PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells

2002 • 165 citations

Rac Regulates Endothelial Morphogenesis and Capillary Assembly

2002 • 160 citations

Paka, a Putative Pak Family Member, Is Required for Cytokinesis and the Regulation of the Cytoskeleton in Dictyostelium discoideum Cells during Chemotaxis

1999 • 159 citations

Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.

1995 • 158 citations

Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts

2000 • 157 citations

Paxillin-dependent Paxillin Kinase Linker and p21-Activated Kinase Localization to Focal Adhesions Involves a Multistep Activation Pathway

2002 • 156 citations

GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6

2000 • 153 citations

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

2000 • 146 citations

Phosphorylation of Pak1 by the p35/Cdk5 Kinase Affects Neuronal Morphology

2001 • 146 citations

The p21-Activated Kinase PAK Is Negatively Regulated by POPX1 and POPX2, a Pair of Serine/Threonine Phosphatases of the PP2C Family

2002 • 144 citations

Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts

1999 • 143 citations

Dynamics of Cytoskeletal Proteins during Fcγ Receptor-mediated Phagocytosis in Macrophages

2002 • 143 citations

Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle

1998 • 143 citations

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1996 • 142 citations

Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

2000 • 141 citations

Two Signaling Mechanisms for Activation of αMβ2 Avidity in Polymorphonuclear Neutrophils

1998 • 140 citations

Distinct cellular effects and interactions of the Rho-family GTPase TC10

1998 • 140 citations

p21‐activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

2002 • 140 citations

Delineation of the Cdc42/Rac-Binding Domain of p21-Activated Kinase

1998 • 139 citations

Missense mutation in PAK3, R67C, causes X-linked nonspecific mental retardation

2000 • 138 citations

The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins

2000 • 134 citations

Identification of the Nef-associated kinase as p21-activated kinase 2

1999 • 132 citations

A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis

2002 • 132 citations

Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

2000 • 132 citations

Interaction between Active Pak1 and Raf-1 Is Necessary for Phosphorylation and Activation of Raf-1

2002 • 131 citations

Etk/Bmx Tyrosine Kinase Activates Pak1 and Regulates Tumorigenicity of Breast Cancer Cells

2001 • 131 citations

Phosphorylation of p85 βPIX, a Rac/Cdc42-specific Guanine Nucleotide Exchange Factor, via the Ras/ERK/PAK2 Pathway Is Required for Basic Fibroblast Growth Factor-induced Neurite Outgrowth

2002 • 131 citations

Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

1998 • 131 citations

Structural Requirements for PAK Activation by Rac GTPases

1998 • 128 citations

Cleavage and Activation of p21-activated Protein Kinase γ-PAK by CPP32 (Caspase 3)

1998 • 128 citations

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

1999 • 128 citations

p95-APP1 links membrane transport to Rac-mediated reorganization of actin

2000 • 125 citations

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1998 • 124 citations

Association of PI-3 Kinase with PAK1 Leads to Actin Phosphorylation and Cytoskeletal Reorganization

2002 • 123 citations

αPix Stimulates p21-activated Kinase Activity through Exchange Factor-dependent and -independent Mechanisms

1999 • 122 citations

Vascular Endothelial Growth Factor Up-regulation via p21-activated Kinase-1 Signaling Regulates Heregulin-β1-mediated Angiogenesis

2000 • 118 citations

Multisite Autophosphorylation of p21-activated Protein Kinase γ-PAK as a Function of Activation

1999 • 114 citations

p21-activated Protein Kinase γ-PAK Suppresses Programmed Cell Death of BALB3T3 Fibroblasts

2001 • 111 citations

p21-activated Kinase 1 Activates the Nuclear Factor κB (NF-κB)-inducing Kinase-IκB Kinases NF-κB Pathway and Proinflammatory Cytokines in Helicobacter pyloriInfection

2000 • 110 citations

A New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment to Focal Adhesions and Cell Migration

2000 • 108 citations

Regulation of the Cool/Pix Proteins

2002 • 108 citations

p21-activated Kinase 1 (PAK1) Interacts with the Grb2 Adapter Protein to Couple to Growth Factor Signaling

2003 • 108 citations

Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

1999 • 105 citations

Activation of LIM Kinases by Myotonic Dystrophy Kinase-related Cdc42-binding Kinase α

2001 • 105 citations

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

2000 • 104 citations

Conformational Switch and Role of Phosphorylation in PAK Activation

2001 • 104 citations

Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak

2001 • 102 citations

Merlin: the neurofibromatosis 2 tumor suppressor

1999 • 101 citations

Activation of Myosin-I by Members of the Ste20p Protein Kinase Family

1996 • 100 citations

Pak1 Phosphorylation on T212 Affects Microtubules in Cells Undergoing Mitosis

2002 • 100 citations

Genetic Evidence for Pak1 Autoinhibition and Its Release by Cdc42

1999 • 98 citations

Flipping the Switch

2000 • 97 citations

Actin cytoskeleton organization regulated by the PAK family of protein kinases

1998 • 96 citations

Regulation of Class I and Class II Myosins by Heavy Chain Phosphorylation

1996 • 95 citations

Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.

1994 • 93 citations

An ADP-Ribosylation Factor GTPase-activating Protein Git2-short/KIAA0148 Is Involved in Subcellular Localization of Paxillin and Actin Cytoskeletal Organization

2001 • 91 citations

A role for Pak protein kinases in Schwann cell transformation

1998 • 91 citations

Pathogenicity island‐dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection

2001 • 91 citations

p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells.

1998 • 90 citations

Angiotensin II Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells

1998 • 89 citations

Cloning and Characterization of a Dictyostelium Myosin I Heavy Chain Kinase Activated by Cdc42 and Rac

1996 • 88 citations

Phosphorylation of Caldesmon by p21-activated Kinase

2000 • 86 citations

Interaction between Nef and Phosphatidylinositol-3-Kinase Leads to Activation of p21-Activated Kinase and Increased Production of HIV

2002 • 85 citations

Rac, a small guanosine triphosphate–binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin α2β1

2001 • 84 citations

A member of the Ste20/PAK family of protein kinases is involved in both arrest of Xenopus oocytes at G2/prophase of the first meiotic cell cycle and in prevention of apoptosis

1997 • 84 citations

Mechanism of activation of Pak1 kinase by membrane localization

1999 • 82 citations

Comparison of Filamin A-induced Cross-linking and Arp2/3 Complex-mediated Branching on the Mechanics of Actin Filaments

2002 • 82 citations

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

2001 • 81 citations

βPix-enhanced p38 Activation by Cdc42/Rac/PAK/MKK3/6-mediated Pathway

2001 • 81 citations

Activation of an S6/H4 Kinase (PAK 65) from Human Placenta by Intramolecular and Intermolecular Autophosphorylation

1995 • 80 citations

Cell Cycle-Regulated Phosphorylation of p21-Activated Kinase 1

2002 • 80 citations

Cutting Edge: p21-Activated Kinase (PAK) Is Required for Fas-Induced JNK Activation in Jurkat Cells

1998 • 78 citations

Molecular Cloning and Sequencing of the Cytostatic G Protein-activated Protein Kinase PAK I

1996 • 77 citations

A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system

1998 • 77 citations

S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3

2001 • 72 citations

Regulation of the p21-activated kinase (PAK) by a human Gβ-like WD-repeat protein, hPIP1

2001 • 69 citations

Human Immunodeficiency Virus Type 1 Nef Selectively Associates with a Catalytically Active Subpopulation of p21-Activated Kinase 2 (PAK2) Independently of PAK2 Binding to Nck or β-PIX

2001 • 66 citations

A p21-Activated Kinase-controlled Metabolic Switch Up-regulates Phagocyte NADPH Oxidase

2002 • 65 citations

LIM-kinase1

1999 • 65 citations

Determinants for Substrate Phosphorylation by p21-Activated Protein Kinase (γ-PAK)

1997 • 64 citations

Neutrophils Stimulated with a Variety of Chemoattractants Exhibit Rapid Activation of p21-Activated Kinases (Paks): Separate Signals Are Required for Activation and Inactivation of Paks

1998 • 63 citations

Reciprocal Signaling between Heterotrimeric G Proteins and the p21-stimulated Protein Kinase

1999 • 62 citations

The Caenorhabditis elegans p21-activated Kinase (CePAK) Colocalizes with CeRac1 and CDC42Ce at Hypodermal Cell Boundaries during Embryo Elongation

1996 • 61 citations

PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress

1999 • 60 citations

Interaction of Paxillin with p21-activated Kinase (PAK)

2001 • 59 citations

Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase)

1998 • 58 citations

p21-activated Protein Kinase γ-PAK Is Activated by Ionizing Radiation and Other DNA-damaging Agents

1999 • 57 citations

Binding of JNK/SAPK to MEKK1 Is Regulated by Phosphorylation

2002 • 56 citations

Lysophosphatidic Acid Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells

2002 • 52 citations

Requirement of p21-activated Kinase (PAK) for Salmonella typhimurium–induced Nuclear Responses

1999 • 51 citations

Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.

2001 • 50 citations

Functional interaction between c-Abl and the p21-activated protein kinase γ-PAK

2000 • 47 citations

Cytostatic p21 G protein-activated protein kinase γ-PAK

2001 • 46 citations

Cdc42/Rac1-Mediated Activation Primes PAK2 for Superactivation by Tyrosine Phosphorylation

2002 • 46 citations

Dual Regulation of Mammalian Myosin VI Motor Function

2001 • 44 citations

Regulation of Xenopus p21-activated Kinase (X-PAK2) by Cdc42 and Maturation-promoting Factor Controls Xenopus Oocyte Maturation

2000 • 43 citations

An Oncogenic Epidermal Growth Factor Receptor Signals via a p21-activated Kinase-Caldesmon-Myosin Phosphotyrosine Complex

2000 • 42 citations

p21-Activated Kinase PAK Phosphorylates Desmin at Sites Different from Those for Rho-Associated Kinase

2000 • 40 citations

Involvement of Alpha-PAK-Interacting Exchange Factor in the PAK1–c-Jun NH₂-Terminal Kinase 1 Activation and Apoptosis Induced by Benzo[a]pyrene

2001 • 38 citations

Structure of the Complex of Cdc42Hs with a Peptide Derived from P-21 Activated Kinase^,

2000 • 37 citations

Mis-specification of cortical identity in a fission yeast PAK mutant

1999 • 35 citations

Vav1 Couples T Cell Receptor to Serum Response Factor-dependent Transcription via a MEK-dependent Pathway

2002 • 35 citations

PAK1 Kinase Is Required for CXCL1-Induced Chemotaxis

2002 • 34 citations

Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.

2002 • 34 citations

Analysis of Small GTPase Signaling Pathways Using p21-activated Kinase Mutants That Selectively Couple to Cdc42

2001 • 33 citations

Direct or C5a-induced Activation of Heterotrimeric Gi2 Proteins in Human Neutrophils Is Associated with Interaction between Formyl Peptide Receptors and the Cytoskeleton

1996 • 33 citations

The p21‐activated kinase, Shk1, is required for proper regulation of microtubule dynamics in the fission yeast, Schizosaccharomyces pombe

2002 • 32 citations

Heat Shock Stress Induces Cleavage and Activation of PAK2 in Apoptotic Cells

1998 • 32 citations

p21‐activated protein kinase γ‐PAK in pituitary secretory granules phosphorylates prolactin

2002 • 30 citations

Characterization of Cbl-Nck and Nck-Pak1 Interactions in Myeloid FcγRII Signaling

1998 • 30 citations

Independent activation of endogenous p21-activated protein kinase-3 (PAK3) and JNK by thrombin in CCL39 fibroblasts

2000 • 9 citations

In vivo activity of wild-type and mutant PAKs

2000 • 5 citations