Structural Basis for the Signaling Specificity of RhoG and Rac1 GTPases

Rho GTPases in cell biology

2002 • 4,662 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

1998 • 667 citations

Rho GTPases

1998 • 534 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Dbl family guanine nucleotide exchange factors

2001 • 414 citations

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1999 • 397 citations

Structural Basis of Rab Effector Specificity

1999 • 347 citations

[75] Assay of transforming activity of tumor virus DNA

1980 • 331 citations

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI

2002 • 326 citations

Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

1999 • 268 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

The role of Rho GTPases in disease development

2002 • 227 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.

2000 • 203 citations

Structure of Cdc42 bound to the GTPase binding domain of PAK.

2000 • 180 citations

Specific Contributions of the Small GTPases Rho, Rac, and Cdc42 to Dbl Transformation

1999 • 177 citations

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

2000 • 170 citations

TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

2000 • 166 citations

RhoG GTPase Controls a Pathway That Independently Activates Rac1 and Cdc42Hs

1998 • 162 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1

1999 • 149 citations

Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells

2000 • 138 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

RhoG Signals in Parallel with Rac1 and Cdc42

2002 • 100 citations

Characterization of the Interactions between the Small GTPase Cdc42 and Its GTPase-activating Proteins and Putative Effectors

1997 • 99 citations

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.

1994 • 90 citations

Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths via RhoG-Mediated Mechanisms

2002 • 88 citations

Functions and Functional Domains of the GTPase Cdc42p

2000 • 85 citations

Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity

2001 • 72 citations

How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42

2001 • 69 citations

Residues of the Rho Family GTPases Rho and Cdc42 That Specify Sensitivity to Dbl-like Guanine Nucleotide Exchange Factors

1997 • 68 citations

Localization of the PAK1-, WASP-, and IQGAP1-specifying Regions of Cdc42

1999 • 58 citations

RhoG regulates gene expression and the actin cytoskeleton in lymphocytes

2003 • 48 citations

Understanding Rho/Rac biology in T‐cells using animal models

2002 • 23 citations