Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

1998 • 3,026 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Regulation of Cell Motility by Mitogen-activated Protein Kinase

1997 • 1,238 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

Rac Downregulates Rho Activity

1999 • 840 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Senescence of human fibroblasts induced by oncogenic Raf

1998 • 805 citations

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

1997 • 772 citations

Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins

1986 • 725 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21^Cip1

1997 • 643 citations

Annual Report to the Nation on the Status of Cancer, 1973-1996, With a Special Section on Lung Cancer and Tobacco Smoking

1999 • 597 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Regulation of Scatter Factor/Hepatocyte Growth Factor Responses by Ras, Rac, and Rho in MDCK Cells

1995 • 547 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1

1997 • 531 citations

Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion

1998 • 505 citations

Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine

1997 • 492 citations

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1

1998 • 468 citations

Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling

1997 • 448 citations

Diaphanous-Related Formins Bridge Rho GTPase and Src Tyrosine Kinase Signaling

2000 • 379 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

A Novel Regulator of p21-activated Kinases

1998 • 313 citations

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

1995 • 304 citations

Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell Polarity

1998 • 297 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

1998 • 266 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion

1992 • 236 citations

Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin

2000 • 229 citations

NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion

1997 • 220 citations

Development of cell surface polarity in the epithelial Madin-Darby canine kidney (MDCK) cell line.

1984 • 220 citations

Morphogenetic Mechanisms of Epithelial Tubulogenesis: MDCK Cell Polarity Is Transiently Rearranged without Loss of Cell–Cell Contact during Scatter Factor/Hepatocyte Growth Factor-Induced Tubulogenesis

1998 • 218 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Alterations in Epithelial Polarity and the Pathogenesis of Disease States

1994 • 200 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • 186 citations

The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

1999 • 179 citations

Distinct Actions and Cooperative Roles of ROCK and mDia in Rho Small G Protein-induced Reorganization of the Actin Cytoskeleton in Madin–Darby Canine Kidney Cells

1999 • 165 citations

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.

1996 • 162 citations

Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells

1997 • 161 citations

Signaling Networks—Do All Roads Lead to the Same Genes?

1999 • 142 citations

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

1996 • 142 citations

Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A.

1994 • 122 citations

Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development

1999 • 118 citations

Involvement of Cdc42 small G protein in cell-cell adhesion, migration and morphology of MDCK cells

1999 • 105 citations

Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal Region Interferes with Ras-dependent Activation of Raf-1

1997 • 100 citations

Multilayering and loss of apical polarity in MDCK cells transformed with viral K-ras.

1991 • 92 citations

Conditional Transformation of Cells and Rapid Activation of the Mitogen-Activated Protein Kinase Cascade by An Estradiol-Dependent Human Raf-1 Protein Kinase

1993 • 86 citations

Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB.

2000 • 78 citations

Hepatocyte Growth Factor Alters the Polarity of Madin-Darby Canine Kidney Cell Monolayers

1997 • 75 citations

Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells

1997 • 73 citations

High-intensity Raf signals convert mitotic cell cycling into cellular growth.

1998 • 72 citations

Internalization efficiency of the transferrin receptor

1992 • 55 citations

Sustained Activation of the Raf-MEK-ERK Pathway Elicits Cytokine Unresponsiveness in T Cells

1999 • 55 citations

Possible involvement of the inactivation of the Rho-Rho-kinase pathway in oncogenic Ras-induced transformation

1998 • 54 citations

Cell polarity and epithelial oncogenesis

1991 • 47 citations

Getting in shape with Rho

2000 • 30 citations