RhoE Binds to ROCK I and Inhibits Downstream Signaling

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and their effector proteins

2000 • 1,941 citations

Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase

1999 • 1,581 citations

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

2001 • 1,239 citations

Cooperation between mDia1 and ROCK in Rho-induced actin reorganization

1999 • 884 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

2001 • 852 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

Ras signalling on the endoplasmic reticulum and the Golgi

2002 • 612 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

2001 • 387 citations

Role of citron kinase as a target of the small GTPase Rho in cytokinesis

1998 • 385 citations

A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion

1998 • 349 citations

Rho-Kinase–Mediated Contraction of Isolated Stress Fibers

2001 • 309 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition

2000 • 290 citations

The COOH Terminus of Rho-kinase Negatively Regulates Rho-kinase Activity

1999 • 271 citations

Identification of a Novel Human Rho Protein with Unusual Properties: GTPase Deficiency and In Vivo Farnesylation

1996 • 265 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue

1998 • 214 citations

RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

1998 • 208 citations

Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi Apparatus

1996 • 200 citations

The PRK2 Kinase Is a Potential Effector Target of both Rho and Rac GTPases and Regulates Actin Cytoskeletal Organization

1997 • 195 citations

The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway

2002 • 184 citations

Antagonistic Effects of Rnd1 and RhoD GTPases Regulate Receptor Activity in Semaphorin 3A-Induced Cytoskeletal Collapse

2002 • 158 citations

Regulation of Protein Transport from the Golgi Complex to the Endoplasmic Reticulum by CDC42 and N-WASP

2002 • 148 citations

The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function

2002 • 146 citations

The Rho-associated protein kinase p160ROCK is required for centrosome positioning

2002 • 140 citations

Identification of the Rho-binding Domain of p160 , a Rho-associated Coiled-coil Containing Protein Kinase

1996 • 137 citations

Different Regions of Rho Determine Rho-selective Binding of Different Classes of Rho Target Molecules

1998 • 119 citations

Involvement of the small GTPases XRhoA and XRnd1 in cell adhesion and head formation in early Xenopus development

1999 • 118 citations

Golgi Vesicle Proteins Are Linked to the Assembly of an Actin Complex Defined by mAbp1

2002 • 114 citations

PRK1 Is Targeted to Endosomes by the Small GTPase, RhoB

1998 • 112 citations

Induced Expression of Rnd3 Is Associated with Transformation of Polarized Epithelial Cells by the Raf–MEK–Extracellular Signal-Regulated Kinase Pathway

2000 • 104 citations

Small GTP-binding Protein TC10 Differentially Regulates Two Distinct Populations of Filamentous Actin in 3T3L1 Adipocytes

2002 • 101 citations

Characterization of RhoA-binding Kinase ROKα Implication of the Pleckstrin Homology Domain in ROKα Function Using Region-specific Antibodies

2002 • 100 citations

Post-transcriptional Down-regulation of ROCKI/Rho-kinase through an MEK-dependent Pathway Leads to Cytoskeleton Disruption in Ras-transformed Fibroblasts

2002 • 82 citations

Small GTPase RhoD suppresses cell migration and cytokinesis

1999 • 77 citations

Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers

2002 • 75 citations

Vesicle budding on Golgi membranes: regulation by G proteins and myosin motors

1998 • 64 citations

A Sec1‐Related Vesicle‐Transport Protein that is Expressed Predominantly in Epithelial Cells

1996 • 63 citations

Prolonged Nuclear Retention of Activated Extracellular Signal-regulated Kinase 1/2 Is Required for Hepatocyte Growth Factor-induced Cell Motility

2002 • 62 citations

RhoGDI‐3 Regulates RhoG and Targets This Protein to the Golgi Complex Through its Unique N‐Terminal Domain

2002 • 53 citations

Post-transcriptional Down-regulation of ROCKI/Rho-kinase through an MEK-dependent Pathway Leads to Cytoskeleton Disruption in Ras-transformed Fibroblasts

2002 • 49 citations

Crystal Structure of the Core Domain of RhoE/Rnd3: A Constitutively Activated Small G Protein^,

2002 • 25 citations

Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family

2000 • 25 citations