IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments

1998 • 1,388 citations

The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly

1999 • 1,332 citations

Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia

1999 • 1,150 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex

1999 • 771 citations

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1998 • 696 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins

2000 • 558 citations

Activation of the Cdc42 Effector N-Wasp by the Shigella flexneri Icsa Protein Promotes Actin Nucleation by Arp2/3 Complex and Bacterial Actin-Based Motility

1999 • 513 citations

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3

2000 • 501 citations

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling

1999 • 407 citations

SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium Development

1998 • 268 citations

The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

1999 • 263 citations

Identification of Two Human WAVE/SCAR Homologues as General Actin Regulatory Molecules Which Associate with the Arp2/3 Complex

1999 • 242 citations

The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

2000 • 242 citations

Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

1998 • 224 citations

Relationship between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells after Epidermal Growth Factor Stimulation

1999 • 199 citations

Characterization and Cloning of a 58/53-kDa Substrate of the Insulin Receptor Tyrosine Kinase

1996 • 99 citations

Phosphorylation of WAVE Downstream of Mitogen-activated Protein Kinase Signaling

1999 • 59 citations