mTOR at the crossroads of T cell proliferation and tolerance

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 • 1,934 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

T Cell Anergy

2003 • 1,418 citations

SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

2006 • 1,365 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

2005 • 1,156 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity

2005 • 526 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Antigen presentation to naive CD4 T cells in the lymph node

2003 • 467 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

2003 • 448 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Egr-2 and Egr-3 are negative regulators of T cell activation

2005 • 431 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome

2003 • 369 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors

2004 • 314 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

Translational control by TOR and TAP42 through dephosphorylation of eIF2α kinase GCN2

2003 • 282 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

2005 • 271 citations

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

2001 • 270 citations

A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy

2007 • 268 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

2006 • 250 citations

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1980 • 250 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

A cellular calculus for signal integration by T cells

2000 • 243 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

E3 ubiquitin ligases as T cell anergy factors

2004 • 224 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin

2003 • 215 citations

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

2005 • 211 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

CD28 Costimulation Mediates Down-Regulation of p27kip1and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells

2002 • 191 citations

Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

2006 • 189 citations

Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

1993 • 184 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.

1993 • 182 citations

The Pim kinases control rapamycin-resistant T cell survival and activation

2005 • 182 citations

Novel roles of Akt and mTOR in suppressing TGF-β/ALK5-mediated Smad3 activation

2005 • 179 citations

Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR

2003 • 172 citations

The Tor Pathway Regulates Gene Expression by Linking Nutrient Sensing to Histone Acetylation

2003 • 156 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells

2004 • 132 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

1999 • 127 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes

2006 • 123 citations

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

1996 • 123 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2α Kinase GCN2

2003 • 101 citations

Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States

2006 • 92 citations

A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance

2006 • 90 citations

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival

2004 • 88 citations

Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

2001 • 85 citations

Continued Antigen Stimulation Is Not Required During CD4+ T Cell Clonal Expansion

2002 • 84 citations

Anergy in Peripheral Memory Cd4+ T Cells Induced by Low Avidity Engagement of T Cell Receptor

2001 • 81 citations

Cutting Edge: CD28-Mediated Transcriptional and Posttranscriptional Regulation of IL-2 Expression Are Controlled through Different Signaling Pathways

2004 • 79 citations

Raf-1 is required for T cell IL2 production.

1993 • 78 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Defective TCR-mediated signaling in anergic T cells.

1995 • 70 citations

Reduced CD3-mediated protein tyrosine phosphorylation in anergic CD4+ and CD8+ T cells.

1993 • 66 citations

A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

2006 • 61 citations

Evidence for Repression of IL-2 Gene Activation in Anergic T Cells

1999 • 55 citations

Vav1 Promotes T Cell Cycle Progression by Linking TCR/CD28 Costimulation to FOXO1 and p27kip1 Expression

2006 • 54 citations

Induction of the increased Fyn kinase activity in anergic T helper type 1 clones requires calcium and protein synthesis and is sensitive to cyclosporin A

1995 • 52 citations

Induction of Anergy in Th1 Cells Associated with Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1 1

2001 • 51 citations

Clonal Anergy Is Maintained Independently of T Cell Proliferation

2002 • 49 citations

The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G1 Cell Cycle Arrest from Tolerance Induction

2004 • 47 citations

TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

2001 • 46 citations

Multiple Signals Required for Cyclic AMP-Responsive Element Binding Protein (CREB) Binding Protein Interaction Induced by CD3/CD28 Costimulation

2001 • 45 citations

Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling

2002 • 42 citations

T Cell Hyporesponsiveness Induced by Oral Administration of Ovalbumin Is Associated with Impaired NFAT Nuclear Translocation and p27kip1Degradation

2002 • 41 citations

Engagement of CD28 Outside of the Immunological Synapse Results in Up-Regulation of IL-2 mRNA Stability but Not IL-2 Transcription

2006 • 34 citations

CD25+Foxp3+ Regulatory T Cells Facilitate CD4+ T Cell Clonal Anergy Induction during the Recovery from Lymphopenia

2006 • 33 citations

CD28 Signaling Augments Elk-1-Dependent Transcription at the c-fosGene During Antigen Stimulation

2001 • 30 citations

Non-parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes

2004 • 25 citations

p300/Cyclic AMP-Responsive Element Binding-Binding Protein Mediates Transcriptional Coactivation by the CD28 T Cell Costimulatory Receptor

2006 • 18 citations

Sustained B7/CD28 interactions and resultant phosphatidylinositol 3‐kinase activity maintain G₁→S phase transitions at an optimal rate

2006 • 14 citations

Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy

2002 • 14 citations

New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models

2004 • 11 citations

Deleted Work

1955 • 0 citations