Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma

2004 • 958 citations

The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway

2004 • 889 citations

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

2001 • 849 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

eIF-4E expression and its role in malignancies and metastases

2004 • 702 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability

2000 • 445 citations

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

2003 • 412 citations

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

2003 • 324 citations

Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors

2004 • 314 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

Pim‐1 kinase promotes inactivation of the pro‐apoptotic Bad protein by phosphorylating it on the Ser¹¹² gatekeeper site

2004 • 308 citations

Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer

2003 • 261 citations

The PIM-2 Kinase Phosphorylates BAD on Serine 112 and Reverses BAD-induced Cell Death

2003 • 251 citations

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

2004 • 245 citations

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways

1997 • 223 citations

Mammalian target of rapamycin inhibition as therapy for hematologic malignancies

2004 • 208 citations

Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

2003 • 199 citations

Will mTOR inhibitors make it as cancer drugs?

2003 • 193 citations

The Molecular Target of Rapamycin (mTOR) as a Therapeutic Target Against Cancer

2003 • 166 citations

Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.

2003 • 160 citations

Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone

2003 • 160 citations

In vivo analysis of Pim-1 deficiency

1993 • 117 citations

Lymphocyte Transformation by Pim-2 Is Dependent on Nuclear Factor-κB Activation

2004 • 87 citations