Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.

1996 • 3,063 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Effective targeted gene ‘knockdown’ in zebrafish

2000 • 2,464 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1996 • 1,473 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Intercellular Trafficking and Protein Delivery by a Herpesvirus Structural Protein

1997 • 962 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

PCR 2 : a practical approach

1995 • 545 citations

Signaling of transforming growth factor‐β family members through Smad proteins

2000 • 530 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

1996 • 416 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Negative Regulation of BMP/Smad Signaling by Tob in Osteoblasts

2000 • 326 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

BTG1, a member of a new family of antiproliferative genes.

1992 • 298 citations

Mammalian Krüppel-like transcription factors: more than just a pretty finger

1999 • 296 citations

POU domain transcription factors

1993 • 278 citations

T cell clonal anergy

1997 • 257 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc–dependent pathway

2001 • 220 citations

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively

1998 • 207 citations

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity.

1996 • 190 citations

Ordering of Human Bone Marrow B Lymphocyte Precursors by Single-Cell Polymerase Chain Reaction Analyses of the Rearrangement Status of the Immunoglobulin H and L Chain Gene Loci

1996 • 186 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

1991 • 185 citations

Blockade of Transforming Growth Factor β/Smad Signaling in T Cells by Overexpression of Smad7 Enhances Antigen-Induced Airway Inflammation and Airway Reactivity

2000 • 177 citations

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

1991 • 166 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

1989 • 143 citations

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases

1999 • 139 citations

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

1994 • 133 citations

Relationships of the Antiproliferative Proteins BTG1 and BTG2 with CAF1, the Human Homolog of a Component of the Yeast CCR4 Transcriptional Complex

2001 • 117 citations

Identification of a Mouse Protein Whose Homolog in Saccharomyces cerevisiae Is a Component of the CCR4 Transcriptional Regulatory Complex

1995 • 109 citations

Transcription factors: A practical approach

1993 • 108 citations

ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

1998 • 107 citations

Transcription factors : a practical approach

1993 • 94 citations

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn.

1992 • 89 citations

A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8; 12)(q24;q22) translocation in a case of B‐cell chronic lymphocytic leukemia

1991 • 87 citations

Synthesis, degradation, and subcellular localization of proteins encoded by the primary response genes TIS7/PC4 and TIS21/PC3

1994 • 38 citations