SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 • 2,574 citations

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

2004 • 2,381 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

2002 • 1,831 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Growing roles for the mTOR pathway

2005 • 1,526 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

The glamour and gloom of glycogen synthase kinase-3

2004 • 1,490 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

Phosphorylation and Functional Inactivation of TSC2 by Erk

2005 • 1,229 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

PKB/Akt

2001 • 1,066 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

2001 • 883 citations

The Akt-mTOR tango and its relevance to cancer

2005 • 778 citations

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

2004 • 737 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

2005 • 621 citations

PKB/AKT: functional insights from genetic models

2001 • 611 citations

FoxO proteins in insulin action and metabolism

2005 • 589 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

PKB Binding Proteins

2002 • 528 citations

Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

2000 • 524 citations

An expanding role for mTOR in cancer

2005 • 519 citations

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

2002 • 492 citations

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

2004 • 485 citations

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

2002 • 416 citations

TSC2: filling the GAP in the mTOR signaling pathway

2003 • 406 citations

The essential role of MEKK3 in TNF-induced NF-κB activation

2001 • 389 citations

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

2001 • 371 citations

Recent advances in the protein kinase B signaling pathway

2005 • 348 citations

Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B

2002 • 333 citations

Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation

2003 • 278 citations

A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation

2002 • 273 citations

mTOR Signaling to Translation

2004 • 255 citations

TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae

2004 • 254 citations

Tor Kinases Are in Distinct Membrane-associated Protein Complexes inSaccharomyces cerevisiae

2003 • 233 citations

TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium

2005 • 196 citations

Complexity of the TOR signaling network

2006 • 191 citations

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

2002 • 187 citations

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

2003 • 183 citations

Protein Kinase B Localization and Activation Differentially Affect S6 Kinase 1 Activity and Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 Phosphorylation

1999 • 175 citations

Protein Kinase C βII Regulates Akt Phosphorylation on Ser-473 in a Cell Type- and Stimulus-specific Fashion

2004 • 167 citations

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

2005 • 157 citations

Kinase phosphorylation: Keeping it all in the family

1999 • 128 citations

Proteomic Analysis of Steady-State Nuclear Hormone Receptor Coactivator Complexes

2005 • 111 citations

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

2004 • 108 citations

Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.

1991 • 107 citations

Tsc2 is not a critical target of Akt during normal Drosophila development

2004 • 102 citations

A Novel Ras-interacting Protein Required for Chemotaxis and Cyclic Adenosine Monophosphate Signal Relay inDictyostelium

1999 • 101 citations

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway

1999 • 65 citations

Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways

2005 • 54 citations

Dimerization through the Catalytic Domain Is Essential for MEKK2 Activation

2005 • 43 citations

Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation

2005 • 43 citations

The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins

2004 • 32 citations