Sustained B7/CD28 interactions and resultant phosphatidylinositol 3‐kinase activity maintain G₁→S phase transitions at an optimal rate

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2003 • 1,803 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

2003 • 702 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

2002 • 580 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

T cell fitness determined by signal strength

2003 • 478 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1

1999 • 317 citations

The immunological synapse and CD28-CD80 interactions

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Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Antigen persistence is required throughout the expansion phase of a CD4+ T cell response

2005 • 271 citations

On the complexity of self

1991 • 261 citations

A cellular calculus for signal integration by T cells

2000 • 243 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides

1997 • 214 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Activated Akt promotes increased resting T cell size, CD28‐independent T cell growth, and development of autoimmunity and lymphoma

2003 • 199 citations

Phosphatidylinositol 3-Kinase Links the Interleukin-2 Receptor to Protein Kinase B and p70 S6 Kinase

1997 • 184 citations

The Pim kinases control rapamycin-resistant T cell survival and activation

2005 • 182 citations

p38 Mitogen-Activated Protein Kinase Mediates Signal Integration of TCR/CD28 Costimulation in Primary Murine T Cells

1999 • 179 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival

2003 • 158 citations

Opposite Translational Control of GLUT1 and GLUT4 Glucose Transporter mRNAs in Response to Insulin

1999 • 152 citations

Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin

2006 • 128 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

Repeated Antigen Exposure Is Necessary for the Differentiation, But Not the Initial Proliferation, of Naive CD4+ T Cells

2002 • 102 citations

Continued Antigen Stimulation Is Not Required During CD4+ T Cell Clonal Expansion

2002 • 84 citations

IκB Kinases Serve as a Target of CD28 Signaling

1998 • 69 citations

The Proliferative Capacity of Individual Naive CD4+T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering

2002 • 59 citations

Clonal Anergy Is Maintained Independently of T Cell Proliferation

2002 • 49 citations

Peripheral Immune Tolerance Blocks Clonal Expansion but Fails to Prevent the Differentiation of Th1 Cells

1998 • 49 citations

A Late, Prolonged Activation of the Phosphatidylinositol 3-Kinase Pathway Is Required for T Cell Proliferation

2004 • 44 citations

Cutting Edge: B7/CD28 Interactions Regulate Cell Cycle Progression Independent of the Strength of TCR Signaling

2002 • 42 citations

Disparate In Vitro and In Vivo Requirements for IL-2 During Antigen-Independent CD8 T Cell Expansion

2004 • 36 citations

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.

1996 • 31 citations

CD28 Signaling Augments Elk-1-Dependent Transcription at the c-fosGene During Antigen Stimulation

2001 • 30 citations

Distinct temporal programming of naive CD4⁺ T cells for cell division versus TCR‐dependent death susceptibility by antigen‐presenting macrophages

2005 • 19 citations