Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

T Cell Anergy

2003 • 1,418 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

Signal transduction and endocytosis: close encounters of many kinds

2002 • 820 citations

Partners in transcription: NFAT and AP-1

2001 • 757 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

The Immunological Synapse Balances T Cell Receptor Signaling and Degradation

2003 • 536 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Polarity of T Cell Shape, Motility, and Sensitivity to Antigen

1996 • 438 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

2002 • 378 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase

2000 • 340 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

1997 • 316 citations

GRAIL

2003 • 280 citations

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

2002 • 276 citations

When cell biology meets development: endocytic regulation of signaling pathways

2002 • 230 citations

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

2000 • 212 citations

Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses

2002 • 172 citations

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

2002 • 172 citations

The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system

2002 • 169 citations

Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

2000 • 147 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.

1994 • 133 citations

Identification of a Novel Proline-Arginine Motif Involved in CIN85-dependent Clustering of Cbl and Down-regulation of Epidermal Growth Factor Receptors

2003 • 131 citations

Pleiotropic Contributions of Phospholipase C-γ1 (PLC-γ1) to T-Cell Antigen Receptor-Mediated Signaling: Reconstitution Studies of a PLC-γ1-Deficient Jurkat T-Cell Line

2000 • 127 citations

Fingerprints of anergic T cells

2001 • 104 citations

Interaction between Two Ubiquitin-Protein Isopeptide Ligases of Different Classes, CBLC and AIP4/ITCH

2002 • 84 citations

CD98 induces LFA‐1‐mediated cell adhesion in lymphoid cells via activation of Rap1

2001 • 66 citations

Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice

2003 • 46 citations

Anergic T Lymphocytes Selectively Express an Integrin Regulatory Protein of the Cytohesin Family

2000 • 37 citations

Regulation of T Cell Activation and Tolerance by Phospholipase Cγ-1-Dependent Integrin Avidity Modulation

2003 • 35 citations

Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4 T Lymphocytes Induced in Vivo by the Oral Administration of Antigen

2003 • 24 citations