A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Smad transcription factors

2005 • 2,366 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Living with or without cyclins and cyclin-dependent kinases

2004 • 1,047 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer

1998 • 562 citations

Assembly of cyclin D-dependent kinase and titration of p27 ^Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

1998 • 497 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

p27^Kip1 modulates cell migration through the regulation of RhoA activation

2004 • 487 citations

Cyclin-dependent kinases regulate the antiproliferative function of Smads

2004 • 485 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Cdc2–cyclin E complexes regulate the G1/S phase transition

2005 • 370 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

2001 • 270 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation

2004 • 240 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

2003 • 163 citations

Loss of Smad3 in Acute T-Cell Lymphoblastic Leukemia

2004 • 162 citations

Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation

2004 • 137 citations

Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

1997 • 131 citations

T Cell Effector Function and Anergy Avoidance Are Quantitatively Linked to Cell Division

2000 • 101 citations

p21Cip1 and p27Kip1 Act in Synergy to Alter the Sensitivity of Naive T Cells to TGF-β-Mediated G1 Arrest through Modulation of IL-2 Responsiveness

2004 • 96 citations

Suppressor activity of anergic T cells induced by IL‐10‐treated human dendritic cells: association with IL‐2‐ and CTLA‐4‐dependent G₁ arrest of the cell cycle regulated by p27^Kip1

2003 • 79 citations

CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes

1999 • 74 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27Kip1 1

2000 • 64 citations

The regulation of p27Kip1 expression following the polyclonal activation of murine G0 T cells.

1997 • 62 citations

Down-Regulation of p27Kip1 Expression Is Required for Development and Function of T Cells

2001 • 59 citations

Opposing Roles for the Cyclin-Dependent Kinase Inhibitor p27kip1in the Control of CD4+ T Cell Proliferation and Effector Function

2005 • 52 citations

Direct Binding of the Signal-transducing Adaptor Grb2 Facilitates Down-regulation of the Cyclin-dependent Kinase Inhibitor p27Kip1

2001 • 38 citations

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

2004 • 33 citations

The Cyclin-Dependent Kinase Inhibitor p27kip1 Is Required for Transplantation Tolerance Induced by Costimulatory Blockade

2006 • 31 citations

Deleted Work

1955 • 0 citations