The immunological synapse and CD28-CD80 interactions

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Mobility measurement by analysis of fluorescence photobleaching recovery kinetics

1976 • 2,658 citations

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

2000 • 2,321 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Cell adhesion. Competition between nonspecific repulsion and specific bonding

1984 • 680 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

Supported planar membranes in studies of cell-cell recognition in the immune system

1986 • 547 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

2001 • 459 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

1991 • 349 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

2001 • 333 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2).

1985 • 229 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.

1992 • 220 citations

Influence of receptor lateral mobility on adhesion strengthening between membranes containing LFA-3 and CD2.

1991 • 213 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 • 176 citations

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

2000 • 158 citations

Number of Receptor Sites from Scatchard and Klotz Graphs: A Constructive Critique

1983 • 149 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Topology of the CD2–CD48 cell-adhesion molecule complex: implications for antigen recognition by T cells

1995 • 124 citations

Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex

1999 • 123 citations

CD28 affects the earliest signaling events generated by TCR engagement

1998 • 110 citations

Activation and differentiation requirements of primary T cells in vitro.

1993 • 102 citations

Construction, purification, and functional incorporation on tumor cells of glycolipid-anchored human B7-1 (CD80).

1995 • 96 citations

Determination of the Relationship Between T Cell Responsiveness and the Number of MHC-Peptide Complexes Using Specific Monoclonal Antibodies

2000 • 93 citations

Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T cells.

1998 • 84 citations

Anti‐CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation I. Pairs of anti‐T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12‐O‐tetradecanoylphorbol 13‐acetate

1986 • 81 citations

CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events

1993 • 74 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

Construction of synthetic signals for glycosyl-phosphatidylinositol anchor attachment. Analysis of amino acid sequence requirements for anchoring.

1993 • 64 citations

Cutting Edge: Stimulation of CD28 with B7–2 Promotes Focal Adhesion-Like Cell Contacts Where Rho Family Small G Proteins Accumulate in T Cells

1998 • 63 citations

Expression of T-cell receptor alpha-chain genes in transgenic mice.

1988 • 60 citations

Autonomous induction of proliferation, JNK and NF-κB activation in primary resting T cells by mobilized CD28

2000 • 34 citations

Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation.

1996 • 32 citations

Intracellular mediators regulate CD2 lateral diffusion and cytoplasmic Ca2+ mobilization upon CD2-mediated T cell activation

1995 • 26 citations

Studies on the two-signal model for T cell activation in vivo.

1987 • 21 citations

High-Level Expression of Biologically Active, Soluble Forms of ICAM-1 in a Novel Mammalian-Cell Expression System

1994 • 11 citations

Induction of T Cell Adhesion by Antigen Stimulation and Modulation by the Coreceptor CD4

1996 • 11 citations