Akt Activation Promotes Degradation of Tuberin and FOXO3a via the Proteasome

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

2001 • 931 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

1999 • 763 citations

Size Control in Animal Development

1999 • 742 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27^KIP1

2000 • 609 citations

The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation

2001 • 542 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

2001 • 517 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability

2000 • 445 citations

Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

2002 • 432 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains

2001 • 405 citations

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

2002 • 373 citations

Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

2001 • 309 citations

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

2002 • 293 citations

The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination

2000 • 257 citations

Ubiquitin‐associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi‐ubiquitin chain assembly

2001 • 211 citations

Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1

2002 • 204 citations

Characterization of the Cytosolic Tuberin-Hamartin Complex

1999 • 182 citations

Multisite Phosphorylation and the Countdown to S Phase

2001 • 136 citations