Induction of Anergy in Th1 Cells Associated with Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1 1

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells

1999 • 226 citations

Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.

1996 • 200 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

1996 • 123 citations

Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in Primary and Established Cells

1998 • 116 citations

Th1 and Th2 clones differ in their response to a tolerogenic signal.

1990 • 102 citations

Butyrate Stimulates Cyclin D and p21 and Inhibits Cyclin-Dependent Kinase 2 Expression in HT-29 Colonic Epithelial Cells

1997 • 101 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Sodium Butyrate Induces NIH3T3 Cells to Senescence-like State and Enhances Promoter Activity of p21WAF/CIP1in p53-Independent Manner

1997 • 92 citations

p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53: important role of RNA stabilization

1999 • 80 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation.

1992 • 64 citations

Sustained Activation of the Raf-MEK-ERK Pathway Elicits Cytokine Unresponsiveness in T Cells

1999 • 55 citations

Ras- and mitogen-activated protein kinase kinase-dependent and -independent pathways in p21Cip1/Waf1 induction by fibroblast growth factor-2, platelet-derived growth factor, and transforming growth factor-beta1.

1999 • 34 citations

Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas.

1995 • 32 citations

Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanism

1996 • 27 citations

Interleukin-2-dependent phosphorylation of the retinoblastoma-susceptibility-gene product p110-115RB in human T-cells

1992 • 10 citations