TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 • 641 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Receptor clustering as a cellular mechanism to control sensitivity

1998 • 617 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

1997 • 501 citations

Selective Events in T Cell Development

1994 • 486 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

1996 • 390 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.

1993 • 266 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.

1993 • 238 citations

Positive and negative selection invoke distinct signaling pathways.

1996 • 234 citations

Single Cell Analysis Reveals Regulated Hierarchical T Cell Antigen Receptor Signaling Thresholds and Intraclonal Heterogeneity for Individual Cytokine Responses of CD4+ T Cells

1997 • 222 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.

1996 • 214 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

Kinetics and Extent of T Cell Activation as Measured with the Calcium Signal

1997 • 194 citations

Altered T Cell Receptor Ligands Trigger a Subset of Early T Cell Signals

1996 • 169 citations

Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.

1994 • 159 citations

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.

1994 • 158 citations

Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells

1998 • 157 citations

Specific Dephosphorylation of the Lck Tyrosine Protein Kinase at Tyr-394 by the SHP-1 Protein-tyrosine Phosphatase

2001 • 146 citations

Feedback Regulation of β-Arrestin1 Function by Extracellular Signal-regulated Kinases

1999 • 136 citations

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.

1990 • 129 citations

Partial signaling by CD8+ T cells in response to antagonist ligands.

1996 • 111 citations

Cross-Antagonism of a T Cell Clone Expressing Two Distinct T Cell Receptors

1999 • 108 citations

Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion

1996 • 106 citations

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

1992 • 105 citations

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

1996 • 99 citations

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

1993 • 90 citations

Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus

1999 • 86 citations

Phosphorylation of serine 59 of p56lck in activated T cells.

1993 • 85 citations

Selective activation of the calcium signaling pathway by altered peptide ligands.

1996 • 83 citations

T Cell Receptor (TCR) Antagonism without a Negative Signal: Evidence from T Cell Hybridomas Expressing Two Independent TCRs

1999 • 73 citations

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains.

1994 • 68 citations

Cooperative enhancement of specificity in a lattice of T cell receptors

2001 • 67 citations

Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.

1995 • 55 citations

Cutting Edge: Dueling TCRs: Peptide Antagonism of CD4+ T Cells with Dual Antigen Specificities

1999 • 51 citations

Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection.

1999 • 50 citations

Cutting Edge: The Tyrosine Phosphatase SHP-1 Regulates Thymocyte Positive Selection

1999 • 48 citations

Cutting Edge: A Test of the Dominant Negative Signal Model for TCR Antagonism

1999 • 46 citations

Hematopoietic Cell Phosphatase (HCP) Regulates p56LCKPhosphorylation and ZAP-70 Binding to T Cell Receptor ζ Chain

1996 • 43 citations

Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling.

1999 • 36 citations

Cutting Edge: Extracellular Signal-Regulated Kinase Activates Syk: A New Potential Feedback Regulation of Fcε Receptor Signaling

1999 • 34 citations

Differential CD3 zeta phosphorylation is not required for the induction of T cell antagonism by altered peptide ligands.

1999 • 29 citations

Differential CD3ζ Phosphorylation Is Not Required for the Induction of T Cell Antagonism by Altered Peptide Ligands

1999 • 24 citations

Supra-Agonist Peptides Enhance the Reactivation of Memory CTL Responses

2000 • 24 citations