Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2002 • 2,945 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 • 1,160 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

2002 • 1,064 citations

Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 • 1,015 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

Akt regulates growth by directly phosphorylating Tsc2

2002 • 932 citations

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 • 909 citations

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 • 812 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 • 648 citations

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

2000 • 615 citations

Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size

2001 • 511 citations

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 • 510 citations

Identification of a Conserved Motif Required for mTOR Signaling

2002 • 472 citations

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

2001 • 449 citations

Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

1999 • 380 citations

Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Tuberous Sclerosis Tumor Suppressor Complex by Phosphorylation of Tuberin

2002 • 373 citations

Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients

1994 • 362 citations

Molecular genetic advances in tuberous sclerosis

2000 • 354 citations

gigas, a Drosophila Homolog of Tuberous Sclerosis Gene Product-2, Regulates the Cell Cycle

1999 • 257 citations

The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth.

1996 • 217 citations

Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

2002 • 207 citations

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

2002 • 201 citations

The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor

1994 • 188 citations

The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites

2002 • 178 citations

The p38 and MK2 Kinase Cascade Phosphorylates Tuberin, the Tuberous Sclerosis 2 Gene Product, and Enhances Its Interaction with 14-3-3

2003 • 165 citations

Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK

1999 • 141 citations

Role of Phosphatidylinositol-3-Kinase in Insulin Receptor Signaling: Studies with Inhibitor, LY294002

1994 • 135 citations

Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif

2002 • 134 citations

Regulation of TSC2 by 14-3-3 Binding

2002 • 112 citations

Distinct Signalling Pathways Mediate Insulin and Phorbol Ester-stimulated Eukaryotic Initiation Factor 4F Assembly and Protein Synthesis in HEK 293 Cells

2000 • 108 citations

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

2001 • 105 citations

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).

2002 • 89 citations

Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin

2002 • 86 citations

14-3-3β Binds to and Negatively Regulates the Tuberous Sclerosis Complex 2 (TSC2) Tumor Suppressor Gene Product, Tuberin

2003 • 76 citations

Identification and Characterization of the Interaction between Tuberin and 14-3-3ζ

2002 • 76 citations

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.

1986 • 68 citations

Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway

2001 • 64 citations