Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

1993 • 592 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Distinct Roles for LFA-1 and CD28 during Activation of Naive T Cells: Adhesion versus Costimulation

1997 • 411 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Methods in molecular genetics

1995 • 319 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

T cell clonal anergy

1997 • 257 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Identification of a Zinc Finger Protein that Inhibits IL-2 Gene Expression

1991 • 195 citations

Regulation of Interferon-γ Gene Expression

1996 • 160 citations

Control of Lytic Function by Mitogen-activated Protein Kinase/Extracellular Regulatory Kinase 2 (ERK2) in a Human Natural Killer Cell Line: Identification of Perforin and Granzyme B Mobilization by Functional ERK2

1998 • 148 citations

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

1989 • 143 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

Role of Transcriptional Repressor ICER in Cyclic AMP-mediated Attenuation of Cytokine Gene Expression in Human Thymocytes

1998 • 112 citations

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2

1998 • 89 citations

Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.

1997 • 87 citations

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.

1996 • 77 citations

Selective Inhibition of IL-Gene Expression by 2Trichostatin A, a Potent Inhibitor of Mammalian Histone Deacetylase.

1996 • 74 citations

Th1 cell anergy and blockade in G1a phase of the cell cycle.

1993 • 72 citations

Negative transcriptional regulation in anergic T cells.

1995 • 66 citations

Persistence of Peptide-induced CD4+ T cell Anergy In Vitro

1998 • 62 citations

Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin–proteasome pathway

1997 • 54 citations

lnterleukin-2 Receptor Signaling Mechanisms

1996 • 54 citations

Regulation of granulocyte‐macrophage colony‐stimulating factor and interleukin 3 expression

1995 • 51 citations

Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.

1996 • 35 citations

Prolonged survival without posttransplant immunosuppression in a large animal model.

1994 • 15 citations

Positive Regulation of the Nuclear Activator CREM by the Mitogen-Induced p70 S6 Kinase

1995 • 11 citations