Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle.

1975 • 1,605 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 709 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Regulatory T cells under scrutiny

2003 • 427 citations

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

2001 • 421 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells

2004 • 323 citations

A peripheral circulating compartment of natural naive CD4+ Tregs

2005 • 299 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

RAPAMYCIN: CLINICAL RESULTS AND FUTURE OPPORTUNITIES1

2001 • 224 citations

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

2003 • 180 citations

Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells

1995 • 166 citations

Anergic T cells act as suppressor cellsin vitro andin vivo

1999 • 144 citations

Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer

2003 • 140 citations

Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the periphery1

2004 • 79 citations