TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

CD28 Costimulation Mediates T Cell Expansion Via IL-2-Independent and IL-2-Dependent Regulation of Cell Cycle Progression

2000 • 199 citations

Molecular regulation of interleukin‐2 expression by CD28 co‐stimulation and anergy

1998 • 190 citations

The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.

1990 • 141 citations

Anergy and Cytokine-Mediated Suppression as Distinct Superantigen-Induced Tolerance Mechanisms in Vivo

1999 • 105 citations

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2

1998 • 89 citations

Role of Costimulation in the Induction of the IL-12/IL-12 Receptor Pathway and the Development of Autoimmunity

2000 • 59 citations

Induction of Anergy in Th1 Cells Associated with Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1 1

2001 • 51 citations

Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow [published erratum appears in Blood 1994 Jun 1;83(11):3424-5]

1994 • 36 citations

Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation.

2000 • 16 citations

Prolonged survival without posttransplant immunosuppression in a large animal model.

1994 • 15 citations

Transient transfection of primary T helper cells by particle-mediated gene transfer

1998 • 13 citations