Engagement of CD28 Outside of the Immunological Synapse Results in Up-Regulation of IL-2 mRNA Stability but Not IL-2 Transcription

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

The Immunological Synapse

2001 • 987 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

1999 • 772 citations

CD28-mediated co-stimulation: a quantitative support for TCR signalling

2003 • 713 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

T-cell-antigen recognition and the immunological synapse

2003 • 587 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Mitogen-Activated Protein Kinase p38 Controls the Expression and Posttranslational Modification of Tristetraprolin, a Regulator of Tumor Necrosis Factor Alpha mRNA Stability

2001 • 449 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

2000 • 375 citations

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

2000 • 374 citations

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

2003 • 368 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

CD28 costimulation promotes the production of Th2 cytokines.

1997 • 299 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation

2005 • 249 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN INFLAMMATION

2002 • 232 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

1987 • 228 citations

Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes

2002 • 223 citations

Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.

1992 • 220 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay

2005 • 201 citations

Nuclear Export of NF90 Is Required for Interleukin-2 mRNA Stabilization

2002 • 187 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

Crystal structure of a soluble CD28-Fab complex

2005 • 161 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export

2000 • 151 citations

c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells

1998 • 145 citations

Protein kinase Cθ: a new essential superstar on the T-cell stage

2000 • 144 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

HuA and Tristetraprolin Are Induced following T Cell Activation and Display Distinct but Overlapping RNA Binding Specificities

2001 • 138 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Regulation of A + U-rich Element-directed mRNA Turnover Involving Reversible Phosphorylation of AUF1

2003 • 130 citations

The Control of mRNA Stability in Response to Extracellular Stimuli

2002 • 127 citations

Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation

1998 • 115 citations

CD28 and Lipid Rafts Coordinate Recruitment of Lck to the Immunological Synapse of Human T Lymphocytes

2004 • 112 citations

CD28 Signaling via VAV/SLP-76 Adaptors

2001 • 107 citations

Formation and function of the immunological synapse

2002 • 106 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

Regulation of Interleukin 2 Gene Expression by CD28 Costimulation in Mouse T-Cell Clones: both Nuclear and Cytoplasmic RNAs Are Regulated with Complex Kinetics

1995 • 92 citations

Activation of CD4⁺ T cells by delivery of the B7 costimulatory signal on bystander antigen‐presenting cells (trans‐costimulation)

1994 • 86 citations

Cutting Edge: CD28-Mediated Transcriptional and Posttranscriptional Regulation of IL-2 Expression Are Controlled through Different Signaling Pathways

2004 • 79 citations

Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation

2004 • 62 citations

Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation

2004 • 57 citations

Rejection of Mouse Cardiac Allografts by Costimulation in trans

2001 • 46 citations

Molecular Mechanisms of IL-2 Gene Regulation Following Costimulation Through LFA-1

2001 • 45 citations

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA

2005 • 43 citations

CD28-Mediated Regulation of mRNA Stability Requires Sequences Within the Coding Region of the IL-2 mRNA

1999 • 40 citations

Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy.

1996 • 40 citations

Cutting Edge: Protein Kinase Cβ Expression Is Critical for Export of IL-2 from T Cells

2001 • 38 citations

Human Fibroblasts Transduced with CD80 or CD86 Efficientlytrans-Costimulate CD4+ and CD8+ T Lymphocytes in HLA-Restricted Reactions: Implications for Immune Augmentation Cancer Therapy and Autoimmunity

1999 • 38 citations

Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells

2003 • 38 citations

Autonomous induction of proliferation, JNK and NF-κB activation in primary resting T cells by mobilized CD28

2000 • 34 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 21 citations

The Destabilization of IL-2 mRNA by a Premature Stop Codon and Its Differential Stabilization byTrans-Acting Inhibitors of Protein Synthesis Do Not Support a Role for Active Translation in mRNA Stability

1999 • 19 citations

Deleted Work

1955 • 0 citations