CD25+Foxp3+ Regulatory T Cells Facilitate CD4+ T Cell Clonal Anergy Induction during the Recovery from Lymphopenia

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

T CELL MEMORY

1998 • 863 citations

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

1983 • 861 citations

The Peptide Ligands Mediating Positive Selection in the Thymus Control T Cell Survival and Homeostatic Proliferation in the Periphery

1999 • 742 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Immunosuppressive strategies in transplantation

1999 • 461 citations

T cell homeostasis in patients with rheumatoid arthritis

2000 • 453 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Homeostatic proliferation is a barrier to transplantation tolerance

2003 • 403 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Designing and Maintaining the Mature TCR Repertoire

1999 • 323 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

Neonates Support Lymphopenia-Induced Proliferation

2003 • 291 citations

Specificity requirements for selection and effector functions of CD25⁺4⁺regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

2002 • 267 citations

Inflammatory cytokines enhance the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells.

1997 • 263 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Autoimmunity in human primary immunodeficiency diseases

2002 • 173 citations

Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire

2004 • 154 citations

Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis

2003 • 144 citations

Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis

2001 • 139 citations

Lymphocyte homeostasis

1997 • 133 citations

A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation

2001 • 130 citations

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

2001 • 124 citations

The new paradigm of T-cell homeostatic proliferation-induced autoimmunity

2004 • 122 citations

Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells

2003 • 121 citations

T cell homeostasis and systemic autoimmunity

2001 • 118 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

Rapamycin Inhibits the Generation of Graft-Versus-Host Disease- and Graft-Versus-Leukemia-Causing T Cells by Interfering with the Production of Th1 or Th1 Cytotoxic Cytokines

1998 • 109 citations

T cell homeostasis and systemic autoimmunity

2001 • 104 citations

Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

2001 • 85 citations

Immune Regulation by Self-Reactive T Cells is Antigen Specific

2004 • 76 citations

A Role for CD28 in Lymphopenia-Induced Proliferation of CD4 T Cells

2004 • 57 citations

CYCLOSPORINE REDUCES DEVELOPMENT OF OBLITERATIVE BRONCHIOLITIS IN A MURINE HETEROTOPIC AIRWAY MODEL

1997 • 53 citations

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

2000 • 49 citations

Peripheral Immune Tolerance Blocks Clonal Expansion but Fails to Prevent the Differentiation of Th1 Cells

1998 • 49 citations

Cyclophosphamide treatment in systemic necrotizing vasculitis and lupus nephritis. How long? How much?

2004 • 28 citations

A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25+CD4 T cells in vivo

2005 • 8 citations