Central tolerance: learning self-control in the thymus

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Negative selection — clearing out the bad apples from the T-cell repertoire

2003 • 494 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Cross-presentation in viral immunity and self-tolerance

2001 • 460 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes

2004 • 381 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

1997 • 315 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

CD40 Ligation Releases Immature Dendritic Cells from the Control of Regulatory CD4+CD25+ T Cells

2003 • 292 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

2004 • 286 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

A defect in central tolerance in NOD mice

2001 • 272 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

2003 • 269 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

Starting at the Beginning: New Perspectives on the Biology of Mucosal T Cells

2004 • 200 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development

2001 • 181 citations

Defective Central Tolerance Induction in NOD Mice: Genomics and Genetics

2005 • 179 citations

The timing of TCRα expression critically influences T cell development and selection

2005 • 179 citations

CCR7 Directs the Migration of Thymocytes into the Thymic Medulla

2004 • 173 citations

Differential Requirement for Rel/Nuclear Factor κB Family Members in Natural Killer T Cell Development

2003 • 158 citations

Receptor editing in developing T cells

2000 • 157 citations

Generalized Resistance to Thymic Deletion in the NOD Mouse

2004 • 157 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo

2002 • 129 citations

Subcellular Localization of the Autoimmune Regulator Protein

2001 • 127 citations

Chromosomal clustering of genes controlled by the aire transcription factor

2005 • 126 citations

T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes

2005 • 126 citations

AIRE and APECED: molecular insights into an autoimmune disease

2005 • 124 citations

NIK-dependent RelB Activation Defines a Unique Signaling Pathway for the Development of Vα14i NKT Cells

2003 • 120 citations

Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor

2002 • 117 citations

Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

1991 • 107 citations

The Fourth Way? Harnessing Aggressive Tendencies in the Thymus

2004 • 107 citations

Rapid deletion of rearranged T cell antigen receptor (TCR) Vα-Jα segment by secondary rearrangement in the thymus: Role of continuous rearrangement of TCR α chain gene and positive selection in the T cell repertoire formation

1998 • 104 citations

Aire: an update

2004 • 102 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

2005 • 89 citations

Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.

1997 • 83 citations

A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection

2003 • 83 citations

Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection

2005 • 81 citations

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals

2004 • 81 citations

The control of apoptosis in lymphocyte selection

2003 • 79 citations

Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells

2002 • 70 citations

The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function

2005 • 70 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

Rules for Gene Usage Inferred from a Comparison of Large-Scale Gene Expression Profiles of T and B Lymphocyte Development

2003 • 63 citations

The Regulated Expression of a Diverse Set of Genes during Thymocyte Positive Selection In Vivo

2004 • 60 citations

T Cell Development in Mice Expressing CD1d Directed by a Classical MHC Class II Promoter

2003 • 57 citations

Analysis of Transcription Factor Expression during Discrete Stages of Postnatal Thymocyte Differentiation

2004 • 56 citations

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

2004 • 54 citations

CTLA-4−/− Mice Display T Cell-apoptosis Resistance Resembling that Ascribed to Autoimmune-prone Non-obese Diabetic (NOD) Mice

2001 • 39 citations

Generation of NK1.1⁺T cell antigen receptor α/β⁺thymocytes associated with intact thymic structure

1997 • 38 citations

Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

2003 • 33 citations

Cutting Edge: Identification of the Targets of Clonal Deletion in an Unmanipulated Thymus

2003 • 29 citations

Negative selection of thymocytes expressing the D10 TCR

2002 • 28 citations

Lymphotoxin α1β2: a critical mediator in Vα14i NKT cell differentiation

2004 • 10 citations