RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen

2000 • 812 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

1998 • 644 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

1996 • 473 citations

RelB Is Essential for the Development of Myeloid-Related CD8α− Dendritic Cells but Not of Lymphoid-Related CD8α+ Dendritic Cells

1998 • 443 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type I assigned to chromosome 21

1994 • 379 citations

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

1996 • 378 citations

Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla

1999 • 293 citations

Mouse models of insulin dependent diabetes: Low‐dose streptozocin‐induced diabetes and nonobese diabetic (NOD) mice

1987 • 246 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Autoimmune polyendocrinopathy – candidosis – ectodermal dystrophy (APECED): autosomal recessive inheritance

1985 • 180 citations

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 • 179 citations

Common Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients of Different Origins

1998 • 171 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

1985 • 126 citations

Mutation analyses of North American APS-1 patients

1999 • 125 citations

B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes.

1994 • 118 citations

AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers

1999 • 113 citations

Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.

1995 • 109 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

Anergy induced by thymic medullary epithelium

1992 • 101 citations

The MouseAireGene: Comparative Genomic Sequencing, Gene Organization, and Expression

1999 • 78 citations

Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epithelium.

1993 • 76 citations

Isolation and Characterization of the MouseAireGene

1999 • 68 citations

Deletion of high-avidity T cells by thymic epithelium.

1995 • 67 citations

The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

1993 • 66 citations

Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.

1993 • 64 citations

Cloning ofAire,the Mouse Homologue of the Autoimmune Regulator (AIRE) Gene Responsible for Autoimmune Polyglandular Syndrome Type 1 (APS1)

1999 • 60 citations

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

1997 • 53 citations

Thymocytes and RelB‐dependent medullary epithelial cells provide growth‐promoting and organization signals, respectively, to thymic medullary stromal cells

1997 • 46 citations

Thymic microenvironmental abnormalities and thymic selection in NZB.H-2bm12 mice.

1993 • 39 citations

Induction of Insulitis in Athymic (Nude) Mice: The Effect of NOD Thymus and Pancreas Transplantation

1995 • 28 citations

Thymus reticulum of autoimmune mice. 3. Ultrastructural study of NOD (non-obese diabetic) mouse thymus.

1991 • 17 citations