The control of apoptosis in lymphocyte selection

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Caspases: killer proteases

1997 • 2,440 citations

The expanding role of mitochondria in apoptosis.

2001 • 2,377 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Mechanisms of Caspase Activation and Inhibition during Apoptosis

2002 • 1,731 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Apoptosis Signaling

2000 • 1,290 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

B Cell Development Pathways

2001 • 1,185 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

Structure of Bax

2000 • 1,066 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Caspase activation: The induced-proximity model

1999 • 920 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

2001 • 889 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Fas Ligand-Induced Apoptosis

1999 • 778 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

2001 • 620 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

2002 • 564 citations

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

2002 • 564 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Control points in early T-cell development

1993 • 429 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

2003 • 387 citations

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

1995 • 305 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

2002 • 293 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

1994 • 252 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

2000 • 220 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1996 • 174 citations

Lymphocyte Development from Stem Cells

1992 • 170 citations

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.

1996 • 161 citations

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1994 • 157 citations

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

2003 • 153 citations

Positive and negative selection of T cells in T-cellreceptor transgenic mice expressing a bcl-2 transgene.

1994 • 147 citations

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

2000 • 142 citations

Selection events operating at various stages in B cell development

2001 • 133 citations

Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells

1997 • 132 citations

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1992 • 130 citations

FAS Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-Activated Protein Kinase

2000 • 105 citations

Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.

1997 • 82 citations

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells

2001 • 79 citations

The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

1994 • 76 citations

In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands

1992 • 72 citations

Jak3 Selectively Regulates Bax and Bcl-2 Expression To Promote T-Cell Development

2001 • 64 citations

Constitutive Bcl-2 Expression during Immunoglobulin Heavy Chain–Promoted B Cell Differentiation Expands Novel Precursor B Cells

1997 • 57 citations

Cell Death Control in Lymphocytes

2001 • 48 citations

Continued differentiation during B lymphopoiesis requires signals in addition to cell survival

1997 • 38 citations

MHC Recognition in Thymic Development: Distinct, Parallel Pathways for Survival and Lineage Commitment

2000 • 22 citations

Lymphomas and Plasmacytomas in Transgenic Mice Involving Bcl2, Myc and v-Abl

1997 • 12 citations