AIRE and APECED: molecular insights into an autoimmune disease

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

The language of covalent histone modifications

2000 • 8,260 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Chromosome territories, nuclear architecture and gene regulation in mammalian cells

2001 • 2,239 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

2001 • 1,046 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Clinical Variation of Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy (APECED) in a Series of 68 Patients

1990 • 1,041 citations

Characterization of the Yeast Transcriptome

1997 • 941 citations

Structure and Function in the Nucleus

1998 • 925 citations

The PHD finger: Implications for chromatin-mediated transcriptional regulation

1995 • 857 citations

How the ubiquitin–proteasome system controls transcription

2003 • 790 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

2001 • 736 citations

The evolutionary dynamics of eukaryotic gene order

2004 • 729 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

The transcriptional role of PML and the nuclear body

2000 • 574 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Evidence for large domains of similarly expressed genes in the Drosophila genome

2002 • 483 citations

The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor

2003 • 467 citations

Perinuclear localization of chromatin facilitates transcriptional silencing

1998 • 466 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

2003 • 458 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Transcriptional regulation by histone ubiquitination and deubiquitination

2003 • 401 citations

Emerging Roles of Ubiquitin in Transcription Regulation

2002 • 395 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Mutations in the AIRE Gene: Effects on Subcellular Location and Transactivation Function of the Autoimmune Polyendocrinopathy-Candidiasis–Ectodermal Dystrophy Protein

2000 • 358 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

2004 • 352 citations

The Ubiquitin Ligase SCF ^Fbw7 Antagonizes Apoptotic JNK Signaling

2004 • 345 citations

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1992 • 319 citations

The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

2002 • 314 citations

Assembly of the Nuclear Transcription and Processing Machinery: Cajal Bodies (Coiled Bodies) and Transcriptosomes

1999 • 291 citations

GRAIL

2003 • 280 citations

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins

1996 • 278 citations

A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients

1998 • 244 citations

Human thymic stromal lymphopoietin promotes dendritic cell–mediated CD4+ T cell homeostatic expansion

2004 • 241 citations

The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein

2000 • 239 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation.

2001 • 222 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Back to Central Tolerance

2004 • 202 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

MHC Class I Ubiquitination by a Viral PHD/LAP Finger Protein

2001 • 199 citations

Promiscuous gene expression and central T-cell tolerance: more than meets the eye

2002 • 198 citations

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

2001 • 197 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

The Contribution of Nuclear Compartmentalization to Gene Regulation

2002 • 185 citations

The Autoimmune Regulator (AIRE) Is a DNA-binding Protein

2001 • 172 citations

Common Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients of Different Origins

1998 • 171 citations

Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

2001 • 166 citations

Structure of the PHD Zinc Finger from Human Williams-Beuren Syndrome Transcription Factor

2000 • 155 citations

Different HATS of the ING1 gene family

2002 • 154 citations

Localization of the APECED protein in distinct nuclear structures

1999 • 154 citations

Sp110 Localizes to the PML-Sp100 Nuclear Body and May Function as a Nuclear Hormone Receptor Transcriptional Coactivator

2000 • 152 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

PHD domains and E3 ubiquitin ligases: viruses make the connection

2002 • 145 citations

The major dermatomyositis‐specific mi‐2 autoantigen is a presumed helicase involved in transcriptional activation

1995 • 140 citations

DEAF-1, a novel protein that binds an essential region in a Deformed response element.

1996 • 138 citations

Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

2004 • 135 citations

Subcellular Localization of the Autoimmune Regulator Protein

2001 • 127 citations

The genetic background of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy and its autoimmune disease components

2002 • 114 citations

AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: altered sub-cellular distribution of mutants lacking the PHD zinc fingers

1999 • 113 citations

APECED-causing mutations in AIRE reveal the functional domains of the protein

2004 • 109 citations

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity

2004 • 103 citations

Identification and Characterization of a Leukocyte-specific Component of the Nuclear Body

1996 • 102 citations

Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen.

1995 • 98 citations

The PHD Type Zinc Finger Is an Integral Part of the CBP Acetyltransferase Domain

2002 • 97 citations

A significant fraction of conserved noncoding DNA in human and mouse consists of predicted matrix attachment regions

2003 • 96 citations

Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED

2001 • 90 citations

Scores of RINGS but No PHDs in Ubiquitin Signaling

2003 • 87 citations

The MouseAireGene: Comparative Genomic Sequencing, Gene Organization, and Expression

1999 • 78 citations

Subcellular Expression of Autoimmune Regulator Is Organized in a Spatiotemporal Manner

2004 • 71 citations

Efficient Inhibition of Escherichia Coli RNA Polymerase by the Bacteriophage T4 AsiA Protein Requires that AsiA Binds First to Free σ70

2000 • 67 citations

Binding of Acf1 to DNA Involves a WAC Motif and Is Important for ACF-Mediated Chromatin Assembly

2002 • 64 citations

Gene expression neighborhoods.

2002 • 54 citations

E3 Ligases in T Cell Anergy—Turning Immune Responses into Tolerance

2004 • 54 citations

Nuclear DEAF-1-related (NUDR) Protein Contains a Novel DNA Binding Domain and Represses Transcription of the Heterogeneous Nuclear Ribonucleoprotein A2/B1 Promoter

1999 • 53 citations

Cloning of the APECED gene provides new insight into human autoimmunity

1999 • 52 citations

The Factor Binding to the Glucocorticoid Modulatory Element of the Tyrosine Aminotransferase Gene Is a Novel and Ubiquitous Heteromeric Complex

1995 • 47 citations

Common Mutations in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients of Different Origins

1998 • 45 citations

Crystal Structure and Nuclear Magnetic Resonance Analyses of the SAND Domain from Glucocorticoid Modulatory Element Binding Protein-1 Reveals Deoxyribonucleic Acid and Zinc Binding Regions

2003 • 44 citations

Ubiquitination--More Than Two to Tango

2000 • 44 citations

Reply to Scheel and Hofmann: Progressing towards a better definition of PHD domains

2003 • 4 citations