DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Germinal Centers

1994 • 1,680 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

1997 • 1,280 citations

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

‘Nude’, a new hairless gene with pleiotropic effects in the mouse

1966 • 834 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

1995 • 800 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

1998 • 760 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

The role of nasopharyngeal lymphoid tissue

1992 • 532 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Antigen localisation regulates immune responses in a dose‐ and time‐dependent fashion: a geographical view of immune reactivity

1997 • 493 citations

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

1996 • 477 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Two Genetically Separable Steps in the Differentiation of Thymic Epithelium

1996 • 447 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

1996 • 405 citations

Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex

1997 • 401 citations

Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.

1996 • 392 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.

1996 • 379 citations

Long-range disruption of gene expression by a selectable marker cassette

1996 • 377 citations

The Follicular Dendritic Cell: Long Term Antigen Retention During Immunity

1980 • 377 citations

Germinal center development

1997 • 370 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

1997 • 348 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

1997 • 318 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 • 296 citations

Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor

1998 • 294 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

THE ROLE OF THE IKAROS GENE IN LYMPHOCYTE DEVELOPMENT AND HOMEOSTASIS

1997 • 262 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Hox11 controls the genesis of the spleen

1994 • 261 citations

Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells

1997 • 254 citations

CD28 is required for germinal center formation.

1996 • 251 citations

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

1998 • 232 citations

Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.

1986 • 231 citations

Structure and function of bronchus-associated lymphoid tissue (BALT).

1989 • 226 citations

Cell-Autonomous Defects in Dendritic Cell Populations of Ikaros Mutant Mice Point to a Developmental Relationship with the Lymphoid Lineage

1997 • 221 citations

Three distinctive steps in Peyer's patch formation of murine embryo

1997 • 205 citations

Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

1997 • 205 citations

Lymphotoxin

1988 • 205 citations

Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG Responses

1997 • 193 citations

Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

1997 • 192 citations

On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11−/−) Mutant Mice

1997 • 190 citations

Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen.

1995 • 188 citations

The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light‐microscopic immunocytochemical studies of mouse spleen, lymph node, and peyer's patch

1984 • 188 citations

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.

1996 • 181 citations

Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions

1997 • 179 citations

Immunological defects in mice with a targeted disruption in Bcl-3.

1997 • 164 citations

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.

1997 • 148 citations

Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.

1995 • 146 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Follicular Dendritic Cells Specifically Express the Long CR2/CD21 Isoform

1997 • 136 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 136 citations

Multifocal defects in immune responses in RelB-deficient mice.

1997 • 131 citations

Distinct Roles of Lymphotoxin α and the Type I Tumor Necrosis Factor (TNF) Receptor in the Establishment of Follicular Dendritic Cells from Non–Bone Marrow–derived Cells

1997 • 131 citations

Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-β receptor–IgG1 fusion protein

1996 • 125 citations

Cytokine regulation of secondary lymphoid organ development

1998 • 123 citations

Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.

1993 • 112 citations

Morphology, function and pathology of follicular dendritic cells

1996 • 109 citations

Follicular Dendritic Cell (FDC) Precursors in Primary Lymphoid Tissues

1998 • 108 citations

Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node

1997 • 105 citations

Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization

1997 • 104 citations

The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system

1997 • 101 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 97 citations

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain.

1996 • 92 citations

Follicular dendritic cells and B cell costimulation.

1993 • 89 citations

The genetics and morphology of two ‘luxoid’ mutants in the house mouse

1964 • 88 citations

Splenic marginal zone lymphocytes and related cells in the lymph node: A morphologic and immunohistochemical study

1989 • 88 citations

A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin β

1998 • 74 citations

Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma.

1991 • 68 citations

Correction or Transfer of Immunodeficiency Due to TNF-LTα Deletion by Bone Marrow Transplantation

1996 • 65 citations

Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice

1996 • 63 citations

Complementation of Lymphotoxin α Knockout Mice with Tumor Necrosis Factor–expressing Transgenes Rectifies Defective Splenic Structure and Function

1998 • 61 citations

Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice

1988 • 58 citations

Development expression of Hox11 and specification of splenic cell fate.

1995 • 54 citations

Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration.

1995 • 53 citations

Chance encounters and organized rendezvous

1997 • 50 citations

TNF Receptor Distribution in Human Tissues

1993 • 48 citations

“PERFEXT”: a direct method for quantitative assessment of cytokine production in vivo at the local level

1997 • 41 citations

The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: Role of the lymphocytes

1994 • 39 citations

The human spleen and the immune system: not just another lymphoid organ

1991 • 37 citations

Characterization of the mouse lymphotoxin-beta gene.

1995 • 35 citations

Natural killer cell development is blocked in the context of aberrant T lymphocyte oxtogeny

1996 • 35 citations

Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice.

1997 • 33 citations

Architecture of the Lymph Node with Regard to Its Function

1990 • 33 citations

Tumor necrosis factor receptor-1 signaling is required for differentiation of follicular dendritic cells, germinal center formation, and full antibody responses.

1995 • 31 citations

Immunological functions of splenic B-lymphocytes.

1992 • 27 citations

Memory B Cells Generated in T Cell-Dependent Antibody Responses Colonise the Splenic Marginal Zone

1988 • 16 citations

Estimation of Blood Flow in the Banti Spleen on Anatomical Basis

1968 • 13 citations

M Cell-Mediated Antigen Transport and Monoclonal IgA Antibodies for Mucosal Immune Protection

1992 • 12 citations

Incomplete development of the spleen and the deformity in the chimeras between asplenic mutant (Dominant hemimelia) and normal mice

1995 • 3 citations