Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

1998 • 504 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

1994 • 353 citations

DO11.10 and OT-II T Cells Recognize a C-Terminal Ovalbumin 323–339 Epitope

2000 • 334 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

Negative Selection in the Thymus Includes Semimature T Cells

1997 • 224 citations

How Many Thymocytes Audition for Selection?

1997 • 222 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo

2002 • 129 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

A Kinetic Threshold between Negative and Positive Selection Based on the Longevity of the T Cell Receptor–Ligand Complex

1999 • 122 citations

Upregulation of surface markers on dying thymocytes.

1995 • 122 citations

Strong TCR Ligation Without Costimulation Causes Rapid Onset of Fas-Dependent Apoptosis of Naive Murine CD4+ T Cells

1999 • 109 citations

Clonal deletion of specific thymocytes by an immunoglobulin idiotype.

1993 • 100 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

Role of CD4 in thymocyte selection and maturation.

1989 • 88 citations

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes

1988 • 84 citations

TNF Receptor-Deficient Mice Reveal Striking Differences Between Several Models of Thymocyte Negative Selection

1998 • 84 citations

EVIDENCE THAT LONG-TERM CARDIAC ALLOGRAFT SURVIVAL INDUCED BY ANTI-CD4 MONOCLONAL ANTIBODY DOES NOT REQUIRE DEPLETION OF CD4+ T CELLS

1992 • 82 citations

Negative Selection of T Cells Occurs Throughout Thymic Development

1999 • 70 citations

Characterization of the murine heat‐stable antigen: An hematolymphoid differentiation antigen defined by the J11d, M1/69 and B2A2 antibodies

1990 • 66 citations

Immature CD4+CD8+ Thymocytes Do Not Polarize Lipid Rafts in Response to TCR-Mediated Signals

2000 • 56 citations

CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation

2000 • 56 citations

Activation-induced apoptosis in lymphoid systems.

1992 • 53 citations

Direct Visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection

1996 • 41 citations

Timing of deletion of autoreactive V _β6+ cells and down-modulation of either CD4 orCD8 on phenotypically distinct CD4+8+ subsets of thymocytes expressingintermediate or high levels of T cell receptor

1991 • 39 citations

A Role for Accessibility to Self-Peptide-Self-MHC Complexes in Intrathymic Negative Selection

2001 • 33 citations

Predominant Transgene Expression in Exocrine Pancreas Directed by the CMV Promoter

2000 • 32 citations

Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation

2002 • 24 citations

Developmental control of antigen-induced thymic transcription factors

1996 • 14 citations