Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77

1994 • 551 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Reciprocal changes in expression of the receptor lin-12 and its ligand lag-2 prior to commitment in a C. elegans cell fate decision

1994 • 254 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

RORγt, a Novel Isoform of an Orphan Receptor, Negatively Regulates Fas Ligand Expression and IL-2 Production in T Cells

1998 • 235 citations

MHC Class II–Specific T Cells Can Develop in the CD8 Lineage When CD4 Is Absent

1996 • 218 citations

Schlafen, a New Family of Growth Regulatory Genes that Affect Thymocyte Development

1998 • 211 citations

Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis.

1996 • 210 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation

2003 • 169 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

Presenilin-dependent γ-secretase activity modulates thymocyte development

2001 • 153 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

Induction of the Early Growth Response (Egr) Family of Transcription Factors during Thymic Selection

1997 • 141 citations

In Vitro Evidence That Cytokine Receptor Signals Are Required for Differentiation of Double Positive Thymocytes into Functionally Mature CD8+ T Cells

2003 • 137 citations

The level of CD8 expression can determine the outcome of thymic selection

1992 • 134 citations

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor

2003 • 126 citations

The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes

1997 • 112 citations

A Reassessment of the Effect of Activated Notch1 on CD4 and CD8 T Cell Development

2002 • 102 citations

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis

1999 • 102 citations

Molecular basis for developmental changes in interleukin-2 gene inducibility.

1993 • 96 citations

FADD-deficient T Cells Exhibit a Disaccord in Regulation of the Cell Cycle Machinery

2001 • 84 citations

Regulated expression of gp130 and IL-6 receptor alpha chain in T cell maturation and activation

1998 • 78 citations

Gene expression analysis of thymocyte selection in vivo

2003 • 57 citations

The CD4/CD8 lineage decision: integration of signalling pathways

2000 • 45 citations

Role of TCR specificity in CD4 versus CD8 lineage commitment.

1995 • 39 citations

Characterization of Transcriptional Regulation During Negative Selection In Vivo

2003 • 39 citations

Highly Efficient Selection of CD4 and CD8 Lineage Thymocytes Supports an Instructive Model of Lineage Commitment

2000 • 36 citations

Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.

1995 • 35 citations

Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

1993 • 30 citations

CD53, a thymocyte selection marker whose induction requires a lower affinity TCR–MHC interaction than CD69, but is up-regulated with slower kinetics

2002 • 30 citations

Cutting Edge: Identification of the Targets of Clonal Deletion in an Unmanipulated Thymus

2003 • 29 citations

Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment

1998 • 26 citations

MHC Recognition in Thymic Development: Distinct, Parallel Pathways for Survival and Lineage Commitment

2000 • 22 citations

Specific regulation of Fos family transcription factors in thymocytes at two developmental checkpoints

1999 • 22 citations

Spontaneous Apoptosis of Thymocytes Is Uncoupled with Progression through the Cell Cycle

1996 • 19 citations

Positive and negative thymic selection in T cell receptor‐transgenic mice correlate with Nur77 mRNA expression

1997 • 17 citations

Activation of Cdk2 is a requirement for antigen-mediated thymic negative selection

2000 • 16 citations

Induction of CCR7 Expression in Thymocytes Requires both ERK Signal and Ca2+ Signal

2001 • 14 citations

Overexpression of TIAP/m-survivin in thymocytes enhances cell proliferation

2002 • 14 citations

Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection

2003 • 8 citations