The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

The Organizing Principle in the Formation of the T Cell Receptor-CD3 Complex

2002 • 408 citations

Antigen Receptor–Induced Activation and Cytoskeletal Rearrangement Are Impaired in Wiskott-Aldrich Syndrome Protein–Deficient Lymphocytes

1999 • 367 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Wiskott-Aldrich Syndrome Protein Physically Associates with Nck through Src Homology 3 Domains

1995 • 315 citations

Interaction of the Nck Adapter Protein with p21-activated Kinase (PAK1)

1996 • 309 citations

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton

2004 • 298 citations

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1996 • 268 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

The Nck family of adapter proteins

2002 • 248 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: intrinsic sensitivity and the role of subunit assembly.

1989 • 228 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1990 • 209 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

1998 • 158 citations

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

2005 • 151 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes

2005 • 126 citations

Inducible Clustering of Membrane-Targeted SH3 Domains of the Adaptor Protein Nck Triggers Localized Actin Polymerization

2004 • 105 citations

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1999 • 98 citations

Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model

1998 • 94 citations

An Improved Method for Generating Retroviral Producer Clones for Vectors Lacking a Selectable Marker Gene

1998 • 84 citations

Adapters in lymphocyte signalling

2001 • 82 citations

Failure to synthesize the CD3-gamma chain. Consequences for T cell antigen receptor assembly, processing, and expression.

1992 • 76 citations

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

2004 • 54 citations

A New Trigger for T Cells

2002 • 53 citations

Requirement of multiple SH3 domains of Nck for ligand binding

1999 • 43 citations

T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta.

1999 • 36 citations

T Lymphocyte Development in the Absence of CD3ε or CD3γδεζ

1999 • 35 citations

Architectural Changes in the TCR:CD3 Complex Induced by MHC:Peptide Ligation

2004 • 33 citations

Molecular motors involved in T cell receptor clusterings

2001 • 31 citations

Cloning, Sequencing, and Overexpression of SH2/SH3 Adaptor Protein Nck from Mouse Thymus

1997 • 17 citations

Plasticity and Rigidity in Adaptor Protein-2-Mediated Internalization of the TCR:CD3 Complex

2005 • 16 citations