Molecular mechanisms of CD4+ T-cell anergy

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

A Genomic and Functional Inventory of Deubiquitinating Enzymes

2005 • 1,737 citations

Positive and Negative Selection of T Cells

2003 • 1,547 citations

T Cell Anergy

2003 • 1,418 citations

Polyubiquitin chains: polymeric protein signals

2004 • 1,002 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

2005 • 856 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Ubiquitin-binding domains

2005 • 786 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

2002 • 658 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Regulation of life and death by the zinc finger transcription factor Egr‐1

2002 • 584 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

2002 • 482 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Egr-2 and Egr-3 are negative regulators of T cell activation

2005 • 431 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

2003 • 400 citations

Ubiquitination on Nonlysine Residues by a Viral E3 Ubiquitin Ligase

2005 • 397 citations

Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes.

1980 • 393 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

2004 • 386 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

2002 • 378 citations

Integration of calcium and RAS signalling

2002 • 375 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

B-cell anergy: from transgenic models to naturally occurring anergic B cells?

2007 • 330 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

1990 • 312 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

Regulation of immunity by self-reactive T cells

2005 • 306 citations

Disruption of diacylglycerol metabolism impairs the induction of T cell anergy

2006 • 281 citations

GRAIL

2003 • 280 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

2006 • 266 citations

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α

2006 • 250 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

E3 ubiquitin ligases as T cell anergy factors

2004 • 224 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

2000 • 211 citations

Rho signalling at a glance

2004 • 209 citations

Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

2003 • 208 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

1998 • 196 citations

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

1987 • 190 citations

SLIM Is a Nuclear Ubiquitin E3 Ligase that Negatively Regulates STAT Signaling

2005 • 186 citations

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

1995 • 185 citations

Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

1993 • 184 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

2003 • 168 citations

WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation

2003 • 159 citations

Regulation of ZAP-70 Activation and TCR Signaling by Two Related Proteins, Sts-1 and Sts-2

2004 • 154 citations

Role of Protein Kinase C in T-Cell Antigen Receptor Regulation of p21^ras: Evidence that Two p21^ras Regulatory Pathways Coexist in Τ Cells

1992 • 151 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

2002 • 143 citations

Suppressors of T-cell Receptor Signaling Sts-1 and Sts-2 Bind to Cbl and Inhibit Endocytosis of Receptor Tyrosine Kinases

2004 • 139 citations

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells

2004 • 132 citations

Ndfip1 Protein Promotes the Function of Itch Ubiquitin Ligase to Prevent T Cell Activation and T Helper 2 Cell-Mediated Inflammation

2006 • 131 citations

Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes

2004 • 129 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways.

1996 • 123 citations

Negative Regulation of the E3 Ubiquitin Ligase Itch via Fyn-Mediated Tyrosine Phosphorylation

2006 • 122 citations

The Ubiquitin Ligase Itch Is Auto-ubiquitylated in Vivo and in Vitro but Is Protected from Degradation by Interacting with the Deubiquitylating Enzyme FAM/USP9X

2006 • 116 citations

N4WBP5, a Potential Target for Ubiquitination by the Nedd4 Family of Proteins, Is a Novel Golgi-associated Protein

2002 • 115 citations

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.

1996 • 115 citations

The HECT Domain Ligase Itch Ubiquitinates Endophilin and Localizes to the trans-Golgi Network and Endosomal System

2004 • 114 citations

Cutting Edge: Cbl-b: One of the Key Molecules Tuning CD28- and CTLA-4-Mediated T Cell Costimulation

2004 • 113 citations

Impaired Activation and Localization of LAT in Anergic T Cells as a Consequence of a Selective Palmitoylation Defect

2006 • 110 citations

Regulation of T Cell Receptor-induced Activation of the Ras-ERK Pathway by Diacylglycerol Kinase ζ

2002 • 109 citations

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling

2003 • 107 citations

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

2006 • 104 citations

The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells

2004 • 99 citations

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation

1997 • 89 citations

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells.

1992 • 85 citations

T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation

1996 • 83 citations

TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

2004 • 80 citations

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

1999 • 75 citations

A Novel E3 Ubiquitin Ligase Substrate Screen Identifies Rho Guanine Dissociation Inhibitor as a Substrate of Gene Related to Anergy in Lymphocytes

2006 • 73 citations

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion

2005 • 69 citations

Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction

2000 • 62 citations

Deltex Regulates T-Cell Activation by Targeted Degradation of Active MEKK1

2005 • 58 citations

Differences Between Responses of Naive and Activated T Cells to Anergy Induction

1998 • 56 citations

Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro

1997 • 55 citations

Evidence for Repression of IL-2 Gene Activation in Anergic T Cells

1999 • 55 citations

A Novel E3 Ubiquitin Ligase TRAC-1 Positively Regulates T Cell Activation

2005 • 52 citations

Examining multiprotein signaling complexes from all angles

2005 • 47 citations

Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.

1997 • 45 citations

The E3 Ubiquitin Ligase GREUL1 Anteriorizes Ectoderm during Xenopus Development

2002 • 29 citations

Establishment of the Major Compatibility Complex-Dependent Development of CD4+ and CD8+ T Cells by the Cbl Family Proteins

2006 • 27 citations

Cloning and Characterization of N4WBP5A, an Inducible, Cyclosporine-sensitive, Nedd4-binding Protein in Human T Lymphocytes

2003 • 27 citations

Constitutive active p21ras enhances primary T cell responsiveness to Ca2+ signals without interfering with the induction of clonal anergy

2002 • 14 citations