Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Mitochondria as the central control point of apoptosis

2000 • 1,875 citations

Endonuclease G is an apoptotic DNase when released from mitochondria

2001 • 1,725 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

The Combined Functions of Proapoptotic Bcl-2 Family Members Bak and Bax Are Essential for Normal Development of Multiple Tissues

2000 • 1,427 citations

Consequences of Cell Death

2000 • 1,382 citations

IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation

1998 • 1,293 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

2001 • 1,106 citations

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1998 • 1,100 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

1999 • 999 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

The Mechanism and Regulation of Chromosomal V(D)J Recombination

2002 • 931 citations

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

2001 • 921 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Control of Homeostasis of CD8 ⁺ Memory T Cells by Opposing Cytokines

2000 • 847 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

2002 • 772 citations

Size Control in Animal Development

1999 • 742 citations

Conformation of the Bax C-terminus regulates subcellular location and cell death

1999 • 723 citations

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

1998 • 704 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

2000 • 556 citations

Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak

1997 • 555 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Caspase Activation Is Required for T Cell Proliferation

1999 • 462 citations

In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability

2000 • 445 citations

RETRACTED: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death

1999 • 443 citations

IL-7 Enhances the Survival and Maintains the Size of Naive T Cells

2001 • 437 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

2001 • 390 citations

Feasting, fasting and fermenting: glucose sensing in yeast and other cells

1999 • 384 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

2001 • 350 citations

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.

1997 • 337 citations

Mitochondria-dependent apoptosis and cellular pH regulation

2000 • 309 citations

The IAP family: endogenous caspase inhibitors with multiple biological activities

2000 • 296 citations

Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX

1998 • 291 citations

An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome

1999 • 291 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Ultrastructural and biochemical characterization of autophagy in higher plant cells subjected to carbon deprivation: control by the supply of mitochondria with respiratory substrates.

1996 • 270 citations

Mouse models of cell death

2001 • 270 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

How αβ T cells deal with induced TCRα ablation

2001 • 224 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Repertoire selection by pre‐B‐cell receptors and B‐cell receptors, and genetic control of B‐cell development from immature to mature B cells

2000 • 216 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

TNF-α Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 196 citations

Mechanisms of life span determination in Caenorhabditis elegans☆

1999 • 177 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Mutations in apoptosis genes: a pathogenetic factor for human disease

2001 • 163 citations

Cabin1 Represses MEF2-Dependent Nur77 Expression and T Cell Apoptosis by Controlling Association of Histone Deacetylases and Acetylases with MEF2

2000 • 156 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells

2000 • 153 citations

RETRACTED: Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes

1999 • 149 citations

Autoimmune lymphoproliferative syndrome

2003 • 146 citations

Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis

2001 • 129 citations

Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP

2000 • 128 citations

The role of cytokine receptor signaling in lymphocyte development

1999 • 118 citations

Effect of haematopoietic cell growth factor on intracellular ATP levels

1983 • 93 citations

Lifespan of lymphocytes

1995 • 87 citations

Regulation of the Fas Death Pathway by FLICE-Inhibitory Protein in Primary Human B Cells

2000 • 76 citations

Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.

1997 • 69 citations

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes.

1996 • 68 citations

Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

2001 • 61 citations

TNF-? Signals Apoptosis through a Bid-Dependent Conformational Change in Bax that Is Inhibited by E1B 19K

2000 • 38 citations

Central T Cell Tolerance in Lupus-Prone Mice: Influence of Autoimmune Background and the lpr Mutation

1998 • 35 citations

Activation sensitizes human memory B cells to B‐cell receptor‐induced apoptosis

1999 • 31 citations

Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice.

1996 • 30 citations

CD95 Antigen Mutations in Hematopoietic Malignancies

2001 • 29 citations

Costimulatory Effect of Fas in Mouse T Lymphocytes

2000 • 10 citations