Regulation of life and death by the zinc finger transcription factor Egr‐1

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Regulation of PTEN Transcription by p53

2001 • 887 citations

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

2001 • 882 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)

1996 • 479 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling

2001 • 390 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

NAB2, a Corepressor of NGFI-A (Egr-1) and Krox20, Is Induced by Proliferative and Differentiative Stimuli

1996 • 353 citations

A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites

1997 • 327 citations

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

2001 • 316 citations

DNA-Binding Specificity of NGFI-A and Related Zinc Finger Transcription Factors

1995 • 304 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells

1995 • 278 citations

Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.

1995 • 258 citations

c-Jun and the transcriptional control of neuronal apoptosis

2000 • 241 citations

A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

1993 • 223 citations

Suppression of growth and transformation and induction of apoptosis by EGR-1.

1998 • 219 citations

Egr-1 Activates Basic Fibroblast Growth Factor Transcription

1996 • 197 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene

2001 • 193 citations

Expression of early growth response genes in human prostate cancer.

1998 • 184 citations

Early Growth Response-1-dependent Apoptosis Is Mediated by p53

1997 • 172 citations

EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis

2000 • 170 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

Impaired prostate tumorigenesis in Egr1-deficient mice

2001 • 162 citations

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.

1995 • 145 citations

Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr‐1, a zinc finger transcriptional regulator

2002 • 133 citations

Stress-induced Stimulation of Early Growth Response Gene-1 by p38/Stress-activated Protein Kinase 2 Is Mediated by a cAMP-responsive Promoter Element in a MAPKAP Kinase 2-independent Manner

1999 • 126 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

c-jun and Egr-1 Participate in DNA Synthesis and Cell Survival in Response to Ionizing Radiation Exposure

1995 • 106 citations

The human transcriptional repressor protein NAB1: expression and biological activity

2000 • 105 citations

A zinc finger directory for high-affinity DNA recognition

1996 • 104 citations

p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

1999 • 95 citations

Binding Studies with Mutants of Zif268

1999 • 89 citations

EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity

2000 • 73 citations

Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells

2001 • 71 citations

A Dominant Negative Egr Inhibitor Blocks Nerve Growth Factor-Induced Neurite Outgrowth by Suppressing c-Jun Activation: Role of an Egr/c-Jun Complex

2002 • 68 citations

Egr-1 inhibits apoptosis during the UV response: correlation of cell survival with Egr-1 phosphorylation

1998 • 68 citations

Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus

2000 • 64 citations

NGFI-A gene expression is necessary for T lymphocyte proliferation.

1993 • 61 citations

Transcription Factor Egr-1 Regulates Glomerular Mesangial Cell Proliferation

1996 • 61 citations

The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells

1998 • 60 citations

The Extracellular Signal-Regulated Protein Kinases Erk1/Erk2 Stimulate Expression and Biological Activity of the Transcriptional Regulator Egr-1

2001 • 60 citations

Differential Regulation of Chromogranin B and Synapsin I Gene Promoter Activity by cAMP and cAMP‐Dependent Protein Kinase

1994 • 58 citations

Early growth response‐1 gene (Egr‐1 ) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro

2002 • 57 citations

Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-κB and extracellular signal-regulated protein kinase activation

2002 • 54 citations

A Dominant Negative Inhibitor of the Egr Family of Transcription Regulatory Factors Suppresses Cerebellar Granule Cell Apoptosis by Blocking c-Jun Activation

2001 • 54 citations

PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements

1993 • 48 citations

Nitric oxide‐induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr‐1, a zinc finger transcription factor

2002 • 46 citations

Promoter Analysis of Tumor Suppressor Gene PTEN: Identification of Minimum Promoter Region

2002 • 40 citations

Method for Cloning In Vivo Targets of the Egr-1 Transcription Factor

2000 • 38 citations

Identification of a Functional cAMP Response Element in the Secretogranin II Gene

1996 • 31 citations

Alteration ofEgr-1 mRNA during multistage carcinogenesis in mouse skin

2000 • 25 citations

Platelet-derived growth factor (PDGF) induction of egr-1 is independent of PDGF receptor autophosphorylation on tyrosine.

1994 • 25 citations