T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex.

1983 • 833 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

The N-end rule

1992 • 464 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.

1995 • 438 citations

Ubiquitination

1991 • 430 citations

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1993 • 312 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

Transmembrane signaling: the joy of aggregation.

1992 • 267 citations

Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.

1985 • 267 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.

1995 • 213 citations

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

1995 • 201 citations

Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

1995 • 194 citations

Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.

1987 • 185 citations

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation.

1992 • 173 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation.

1988 • 167 citations

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

1992 • 146 citations

Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.

1987 • 133 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases

1994 • 125 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down modulation in M07e cells

1994 • 119 citations

A new subunit of the human T-cell antigen receptor complex

1986 • 108 citations

Familial Defect in the Surface Expression of the T-Cell Receptor–CD3 Complex

1988 • 103 citations

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

1993 • 102 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line.

1992 • 82 citations

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations.

1992 • 81 citations

Biochemical Characterization of the η Chain of the T-cell Receptor

1989 • 80 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor

1992 • 58 citations

Pervanadate simulates the effects of interleukin-2 (IL-2) in human T cells and provides evidence for the activation of two distinct tyrosine kinase pathways by IL-2.

1994 • 56 citations

Phosphorylation of multiple CD3 zeta tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation.

1992 • 50 citations

The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation.

1987 • 48 citations

Protein ubiquitination is regulated by phosphorylation. An in vitro study.

1992 • 41 citations

Transcriptional regulation of the T cell antigen receptor zeta subunit: identification of a tissue-restricted promoter.

1994 • 31 citations

Mutagenesis of T cell antigen receptor zeta chain tyrosine residues. Effects on tyrosine phosphorylation and lymphokine production.

1992 • 31 citations

The T-Cell Antigen Receptor: A Multisubunit Signaling Complex

1994 • 18 citations

Tyrosine Protein Kinases in T Lymphocytes

1994 • 14 citations

The T-Cell Antigen Receptor: A Multisubunit Signaling Complex

2015 • 6 citations

Tyrosine Protein Kinases in T Lymphocytes

2015 • 3 citations