Enhanced T cell responses due to diacylglycerol kinase ζ deficiency

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

MAP Kinases in the Immune Response

2002 • 1,620 citations

Protein kinase C

1991 • 914 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

PKCγ mutant mice exhibit mild deficits in spatial and contextual learning

1993 • 532 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Goα and Diacylglycerol Kinase Negatively Regulate the Gqα Pathway in C. elegans

1999 • 301 citations

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

1999 • 284 citations

T Cell Activation and the Cytoskeleton

2000 • 264 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Homeostasis of αβ TCR+ T cells

2000 • 251 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

Properties and functions of diacylglycerol kinases

2000 • 245 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain

1998 • 232 citations

Novel “Nonkinase” Phorbol Ester Receptors: The C1 Domain Connection

2002 • 224 citations

Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

2000 • 211 citations

Phosphatidic acid: A lipid messenger involved in intracellular and extracellular signalling

1996 • 189 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ

2000 • 169 citations

Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ

1996 • 167 citations

Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells

2003 • 163 citations

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

1997 • 163 citations

Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats.

1993 • 155 citations

A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.

1996 • 155 citations

Involvement of p21^ras activation in T cell CD69 expression

1994 • 154 citations

Diacylglycerol kinase ɛ regulates seizure susceptibility and long-term potentiation through arachidonoyl– inositol lipid signaling

2001 • 154 citations

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

1992 • 146 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling

2001 • 141 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Positive and negative regulation of t-cell activation by adaptor proteins

2001 • 137 citations

MAP-kinase signaling pathways in T cells

2001 • 133 citations

Role of zetaPKC in B-cell signaling and function

2002 • 132 citations

Pleiotropic Contributions of Phospholipase C-γ1 (PLC-γ1) to T-Cell Antigen Receptor-Mediated Signaling: Reconstitution Studies of a PLC-γ1-Deficient Jurkat T-Cell Line

2000 • 127 citations

Cooperation between Syk and Rac1 Leads to Synergistic JNK Activation in T Lymphocytes

1998 • 125 citations

NF-κB activation induced by TCR/CD28 costimulation is mediated by PKC-θ

2000 • 124 citations

Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain

1992 • 120 citations

Interaction of γ1-Syntrophin with Diacylglycerol Kinase-ζ

2001 • 111 citations

Diacylglycerol Kinase ζ Regulates Ras Activation by a Novel Mechanism

2001 • 110 citations

Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension

2001 • 109 citations

Regulation of T Cell Receptor-induced Activation of the Ras-ERK Pathway by Diacylglycerol Kinase ζ

2002 • 109 citations

Presentation of endogenous viral proteins in association with major histocompatibility complex class II: On the role of intracellular compartmentalization, invariant chain and the TAP transporter system

1995 • 106 citations

T Cell Activation In Vivo Targets Diacylglycerol Kinase α to the Membrane: A Novel Mechanism for Ras Attenuation

2003 • 99 citations

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line

2002 • 96 citations

Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1.

1997 • 95 citations

Diacylglycerol kinase-θ is localized in the speckle domains of the nucleus

2003 • 92 citations

Src-mediated activation of alpha-diacylglycerol kinase is required for hepatocyte growth factor-induced cell motility

2000 • 91 citations

Diacylglycerol Kinase θ Binds to and Is Negatively Regulated by Active RhoA

1999 • 89 citations

Vav-Rac1-Mediated Activation of the c-Jun N-Terminal Kinase/c-Jun/AP-1 Pathway Plays a Major Role in Stimulation of the Distal NFAT Site in the Interleukin-2 Gene Promoter

2001 • 82 citations

Diacylglycerol Kinase δ Suppresses ER-to-Golgi Traffic via Its SAM and PH Domains

2002 • 66 citations

Chemokine receptors in lymphoid organ homeostasis

1999 • 63 citations

Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism

1999 • 58 citations

Roles of Phospholipase Cβ4 in Synapse Elimination and Plasticity in Developing and Mature Cerebellum

2001 • 52 citations

Nuclear Diacylglycerol Kinase-θ Is Activated in Response to α-Thrombin

2001 • 48 citations

Diacylglycerol Kinase ζ in Hypothalamus Interacts with Long Form Leptin Receptor

2001 • 42 citations

Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells

2001 • 23 citations

Participation of Diacylglycerol Kinase in Mitogenic Signal Transduction Induced by Platelet-Derived Growth Factor in Vascular Smooth Muscle Cells

1994 • 12 citations

Fatty acids inhibit growth-factor-induced diacylglycerol kinase α activation in vascular smooth-muscle cells

2001 • 10 citations