The HECT Domain Ligase Itch Ubiquitinates Endophilin and Localizes to the trans-Golgi Network and Endosomal System

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Degradation of CFTR by the ubiquitin-proteasome pathway

1995 • 1,285 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

Receptor downregulation and multivesicular-body sorting

2002 • 1,192 citations

The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and Their Expression

1996 • 1,132 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Mannose 6-phosphate receptors: new twists in the tale

2003 • 1,021 citations

Distinct Membrane Domains on Endosomes in the Recycling Pathway Visualized by Multicolor Imaging of Rab4, Rab5, and Rab11

2000 • 987 citations

Signal transduction and endocytosis: close encounters of many kinds

2002 • 820 citations

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

2002 • 692 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

2002 • 626 citations

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

2001 • 589 citations

Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptors

2002 • 571 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

2002 • 468 citations

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

2003 • 448 citations

A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

2001 • 438 citations

Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

2002 • 417 citations

The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

1997 • 383 citations

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

2002 • 378 citations

Ubiquitination and Endocytosis of Plasma Membrane Proteins: Role of Nedd4/Rsp5p Family of Ubiquitin-Protein Ligases

2000 • 356 citations

Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes

2002 • 338 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis

1999 • 328 citations

Endophilin Mutations Block Clathrin-Mediated Endocytosis but Not Neurotransmitter Release

2002 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

2000 • 321 citations

When ubiquitin meets ubiquitin receptors: a signalling connection

2003 • 303 citations

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

2003 • 298 citations

Fission and Uncoating of Synaptic Clathrin-Coated Vesicles Are Perturbed by Disruption of Interactions with the SH3 Domain of Endophilin

2000 • 297 citations

A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain

2003 • 285 citations

SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation

1999 • 275 citations

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates

2002 • 264 citations

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

1991 • 247 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

2003 • 214 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

The Tight Junction-specific Protein Occludin Is a Functional Target of the E3 Ubiquitin-protein Ligase Itch

2002 • 189 citations

Mosaic Organization of the Endocytic Pathway

2002 • 170 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

Alix (ALG-2-interacting Protein X), a Protein Involved in Apoptosis, Binds to Endophilins and Induces Cytoplasmic Vacuolization

2002 • 168 citations

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.

1994 • 160 citations

WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation

2003 • 159 citations

Multiple Roles for Rsp5p-dependent Ubiquitination at the Internalization Step of Endocytosis

2001 • 147 citations

Apical Membrane Targeting of Nedd4 Is Mediated by an Association of Its C2 Domain with Annexin Xiiib

2000 • 147 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

The Epstein–Barr Virus Latent Membrane Protein 2A PY Motif Recruits WW Domain-Containing Ubiquitin-Protein Ligases

2000 • 141 citations

WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains

2003 • 139 citations

Synaptojanin Forms Two Separate Complexes in the Nerve Terminal

1997 • 138 citations

Domains of the Rsp5 Ubiquitin-Protein Ligase Required for Receptor-mediated and Fluid-Phase Endocytosis

2001 • 135 citations

The SH3 Domains of Endophilin and Amphiphysin Bind to the Proline-rich Region of Synaptojanin 1 at Distinct Sites That Display an Unconventional Binding Specificity

1999 • 128 citations

Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction

2002 • 122 citations

Polyubiquitination of the Epidermal Growth Factor Receptor Occurs at the Plasma Membrane upon Ligand-induced Activation

2000 • 104 citations

Human ubiquitin‐protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin‐conjugating enzymes

1998 • 101 citations

Localization of the Rsp5p Ubiquitin-Protein Ligase at Multiple Sites within the Endocytic Pathway

2001 • 92 citations

PCR Protocols: current methods and applications

1993 • 87 citations

Interaction between Two Ubiquitin-Protein Isopeptide Ligases of Different Classes, CBLC and AIP4/ITCH

2002 • 84 citations

Site-Directed Mutagenesis by Double Polymerase Chain Reaction: Megaprimer Method

2003 • 70 citations

Vps9p CUE Domain Ubiquitin Binding Is Required for Efficient Endocytic Protein Traffic

2003 • 67 citations

Adenovirus Protein Involved in Virus Internalization Recruits Ubiquitin−Protein Ligases

2002 • 57 citations

Endophilin Regulates JNK Activation through Its Interaction with the Germinal Center Kinase-like Kinase

2001 • 53 citations

Human ITCH Is a Coregulator of the Hematopoietic Transcription Factor NF-E2

2001 • 24 citations