Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

RING Finger Proteins

2000 • 1,216 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Regulatory functions of ubiquitination in the immune system

2002 • 392 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

The expanding world of co-stimulation: the two-signal model revisited

2001 • 214 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation

1999 • 179 citations

Complexes of Focal Adhesion Kinase (FAK) and Crk-associated Substrate (p130Cas) Are Elevated in Cytoskeleton-associated Fractions following Adhesion and Src Transformation

1997 • 166 citations

Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70

2001 • 162 citations

Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex

2001 • 160 citations

TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway

1999 • 148 citations

CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation

2000 • 95 citations

CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis

1999 • 82 citations

Molecular Regulation of the IL‐2 Gene: Rheostatic Control of the Immune System

1993 • 64 citations

Lymphocyte signaling: Cbl sets the threshold for autoimmunity

2000 • 51 citations

Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase

2000 • 23 citations