Ndfip1 Protein Promotes the Function of Itch Ubiquitin Ligase to Prevent T Cell Activation and T Helper 2 Cell-Mediated Inflammation

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

2001 • 562 citations

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

2004 • 512 citations

Ubiquitination: RING for destruction?

2000 • 496 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Transcriptional regulation in the immune system: all roads lead to AP-1

1998 • 388 citations

Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

2004 • 386 citations

Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo

2001 • 383 citations

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1999 • 364 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1998 • 328 citations

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

2002 • 326 citations

Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy

1992 • 280 citations

Ubiquitin Ligases and the Immune Response

2004 • 277 citations

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

2006 • 266 citations

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

2003 • 247 citations

Disruption of the β subunit of the epithelial Na ⁺ channel in mice: Hyperkalemia and neonatal death associated with a pseudohypoaldosteronism phenotype

1999 • 243 citations

WW Domains Provide a Platform for the Assembly of Multiprotein Networks

2005 • 241 citations

Immunity by ubiquitylation: a reversible process of modification

2005 • 238 citations

Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets

1997 • 163 citations

WW Domain HECT E3s Target Cbl RING Finger E3s for Proteasomal Degradation

2003 • 159 citations

Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins

2004 • 152 citations

AIRE Functions As an E3 Ubiquitin Ligase

2004 • 145 citations

PHD domains and E3 ubiquitin ligases: viruses make the connection

2002 • 145 citations

Nedd4 mediates control of an epithelial Na ⁺ channel in salivary duct cells by cytosolic Na ⁺

1998 • 140 citations

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB

2002 • 137 citations

Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

2004 • 135 citations

Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.

1995 • 125 citations

All Three WW Domains of Murine Nedd4 Are Involved in the Regulation of Epithelial Sodium Channels by Intracellular Na+

1999 • 123 citations

N4WBP5, a Potential Target for Ubiquitination by the Nedd4 Family of Proteins, Is a Novel Golgi-associated Protein

2002 • 115 citations

The WW module competes with the SH3 domain?

1996 • 112 citations

Regulation of the cardiac voltage‐gated Na⁺ channel (H1) by the ubiquitin‐protein ligase Nedd4

2000 • 110 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 106 citations

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

2006 • 104 citations

Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase

2002 • 77 citations

Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo.

1994 • 55 citations

Increased Numbers of Th2-Like CD4+ T Cells in Target Organs and in the Allergen-Specific Repertoire of Allergic Patients

1991 • 41 citations

A Molecular Dissection of Lymphocyte Unresponsiveness Induced by Sustained Calcium Signalling

2005 • 24 citations

A Novel Family of Retroviral Vectors for the Rapid Production of Complex Stable Cell Lines

2001 • 23 citations

T cells, cytokines, IgE and allergic airways inflammation.

1994 • 16 citations

Target-Assisted Iterative Screening Reveals Novel Interactors for PSD95, Nedd4, Src, Abl and Crk proteins

2002 • 16 citations