SLIM Is a Nuclear Ubiquitin E3 Ligase that Negatively Regulates STAT Signaling

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Regulation of JAK–STAT signalling in the immune system

2003 • 1,313 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

2003 • 783 citations

LIM domains: multiple roles as adapters and functional modifiers in protein interactions

1998 • 592 citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

2001 • 555 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

2002 • 482 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription

2001 • 475 citations

IL-21 Limits NK Cell Responses and Promotes Antigen-Specific T Cell Activation

2002 • 470 citations

Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Ubiquitin Ligases and the Immune Response

2004 • 277 citations

Structure of the Amino-Terminal Protein Interaction Domain of STAT-4

1998 • 267 citations

A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1

1999 • 207 citations

Regulation of E2F through ubiquitin–proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein

1997 • 198 citations

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

2001 • 197 citations

A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b

2000 • 183 citations

Protein-tyrosine Phosphatase Shp-1 Is a Negative Regulator of IL-4- and IL-13-dependent Signal Transduction

1998 • 168 citations

Identification of Shp-2 as a Stat5A Phosphatase

2003 • 123 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

Itch E3 Ligase-Mediated Regulation of TGF-β Signaling by Modulating Smad2 Phosphorylation

2004 • 116 citations

Regulation of the Dephosphorylation of Stat6

2003 • 70 citations

Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity

2004 • 65 citations

Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation

2001 • 40 citations