Regulation of T Cell Receptor-induced Activation of the Ras-ERK Pathway by Diacylglycerol Kinase ζ

MAP Kinases in the Immune Response

2002 • 1,620 citations

LAT

1998 • 1,251 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

2000 • 420 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Transcriptional regulation in the immune system: all roads lead to AP-1

1998 • 388 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Quantitative Analysis of the Complex between p21 and the Ras-binding Domain of the Human Raf-1 Protein Kinase

1995 • 348 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Immunocytochemical Localization of Eight Protein Kinase C Isozymes Overexpressed in NIH 3T3 Fibroblasts

1995 • 302 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

Mammalian Diacylglycerol Kinases, a Family of Lipid Kinases with Signaling Functions

1999 • 284 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Protein kinase C regulates the nuclear localization of diacylglycerol kinase-ζ

1998 • 256 citations

Properties and functions of diacylglycerol kinases

2000 • 245 citations

Phospholipase C-γ as a Signal-Transducing Element

1999 • 242 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

1994 • 233 citations

Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain

1998 • 232 citations

Porcine diacylglycerol kinase sequence has zinc finger and E–F hand motifs

1990 • 218 citations

Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

2000 • 211 citations

T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1

1991 • 201 citations

INTEGRATION OF T CELL RECEPTOR–DEPENDENT SIGNALING PATHWAYS BY ADAPTER PROTEINS

1999 • 197 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.

1987 • 185 citations

Molecular Cloning and Characterization of a Novel Human Diacylglycerol Kinase ζ

1996 • 167 citations

Molecular Cloning of a Novel Diacylglycerol Kinase Isozyme with a Pleckstrin Homology Domain and a C-terminal Tail Similar to Those of the EPH Family of Protein-tyrosine Kinases

1996 • 163 citations

A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.

1996 • 155 citations

Involvement of p21^ras activation in T cell CD69 expression

1994 • 154 citations

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

1999 • 147 citations

Requirement for the SLP-76 Adaptor GADS in T Cell Development

2001 • 145 citations

Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling

2001 • 141 citations

Positive and negative regulation of t-cell activation by adaptor proteins

2001 • 137 citations

Activation of the Lck Tyrosine Kinase Targets Cell Surface T Cell Antigen Receptors for Lysosomal Degradation

1997 • 132 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

1996 • 129 citations

Pleiotropic Contributions of Phospholipase C-γ1 (PLC-γ1) to T-Cell Antigen Receptor-Mediated Signaling: Reconstitution Studies of a PLC-γ1-Deficient Jurkat T-Cell Line

2000 • 127 citations

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation

1999 • 121 citations

Phosphatidic Acid Generation through Interleukin 2 (IL-2)-induced α-Diacylglycerol Kinase Activation Is an Essential Step in IL-2-mediated Lymphocyte Proliferation

1996 • 118 citations

Interaction of γ1-Syntrophin with Diacylglycerol Kinase-ζ

2001 • 111 citations

Diacylglycerol Kinase ζ Regulates Ras Activation by a Novel Mechanism

2001 • 110 citations

Differential Requirement for SLP-76 Domains in T Cell Development and Function

2001 • 104 citations

Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1.

1997 • 95 citations

Cbl and Cbl-b in T-cell regulation

2002 • 85 citations

Expression and Biochemical Characterization of Human Protein Kinase C‐θ

1994 • 83 citations

c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.

1996 • 81 citations

SLP-76 and Vav Function in Separate, but Overlapping Pathways to Augment Interleukin-2 Promoter Activity

1999 • 70 citations

Expression of a catalytically inactive form of diacylglycerol kinase α induces sustained signaling through RasGRP

2002 • 69 citations

Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism

1999 • 58 citations

Molecular determinants of TCR expression and selection

2001 • 57 citations

Alternative splicing of the human diacylglycerol kinase ζ gene in muscle

1997 • 55 citations

Diacylglycerol Kinase ζ in Hypothalamus Interacts with Long Form Leptin Receptor

2001 • 42 citations

The cloning and developmental regulation of murine diacylglycerol kinase ζ

1998 • 26 citations

Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN

2002 • 18 citations