B-cell anergy: from transgenic models to naturally occurring anergic B cells?

Predominant Autoantibody Production by Early Human B Cell Precursors

2003 • 1,966 citations

Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

2002 • 1,877 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

1999 • 1,464 citations

Receptor editing in self-reactive bone marrow B cells.

1993 • 1,026 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

BAFF and APRIL: A Tutorial on B Cell Survival

2003 • 946 citations

Receptor editing: an approach by autoreactive B cells to escape tolerance.

1993 • 920 citations

Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication

2006 • 862 citations

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement

2005 • 788 citations

Excess BAFF Rescues Self-Reactive B Cells from Peripheral Deletion and Allows Them to Enter Forbidden Follicular and Marginal Zone Niches

2004 • 711 citations

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF

2004 • 564 citations

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position

2002 • 558 citations

Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation

2001 • 548 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1991 • 485 citations

Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse.

1987 • 473 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

2002 • 411 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Different Nuclear Signals Are Activated by the B Cell Receptor during Positive Versus Negative Signaling

1997 • 383 citations

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance

2001 • 348 citations

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.

1994 • 340 citations

Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

1999 • 321 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance

2001 • 277 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

Identification of Anergic B Cells within a Wild-Type Repertoire

2006 • 272 citations

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

2002 • 265 citations

Inhibition of the B Cell by CD22: A Requirement for Lyn

1998 • 265 citations

Reduced life span of anergic self-reactive B cells in a double-transgenic model.

1994 • 256 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

The Impact of T Helper and T Regulatory Cells on the Regulation of Anti-Double-Stranded DNA B Cells

2002 • 220 citations

Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling

2005 • 218 citations

Nucleosomes Are Exposed at the Cell Surface in Apoptosis

2004 • 217 citations

Resistance to CpG DNA–induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling

2003 • 184 citations

Regulation of Anti–double-stranded DNA B Cells in Nonautoimmune Mice: Localization to the T–B Interface of the Splenic Follicle

1997 • 176 citations

VH4-34 encoded antibodies in systemic lupus erythematosus: a specific diagnostic marker that correlates with clinical disease characteristics.

1999 • 174 citations

Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity

2002 • 165 citations

Activation and Anergy in Bone Marrow B Cells of a Novel Immunoglobulin Transgenic Mouse that Is Both Hapten Specific and Autoreactive

2001 • 151 citations

Regulation of B-cell survival by BAFF-dependent PKCδ-mediated nuclear signalling

2004 • 143 citations

MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti–double-stranded DNA B Cells

1999 • 135 citations

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

1994 • 111 citations

Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens

1998 • 103 citations

Identification of normal B‐cell counterparts of neoplastic cells which secrete cold agglutinins of anti‐I and anti‐i specificity

1989 • 101 citations

Repression of B7.2 on Self-reactive B Cells Is Essential to Prevent Proliferation and Allow Fas-mediated Deletion by CD4+ T Cells

1998 • 96 citations

Asymmetrical Phosphorylation and Function of Immunoreceptor Tyrosine-Based Activation Motif Tyrosines in B Cell Antigen Receptor Signal Transduction

1998 • 91 citations

Entry of B Cell Receptor into Signaling Domains Is Inhibited in Tolerant B Cells

2000 • 88 citations

Lifespan of lymphocytes

1995 • 87 citations

Early Preplasma Cells Define a Tolerance Checkpoint for Autoreactive B Cells

2006 • 87 citations

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells

2004 • 83 citations

Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process

1999 • 83 citations

ERK Signaling Is a Molecular Switch Integrating Opposing Inputs from B Cell Receptor and T Cell Cytokines to Control TLR4-Driven Plasma Cell Differentiation

2006 • 77 citations

Uncoupling of Anergy from Developmental Arrest in Anti-Insulin B Cells Supports the Development of Autoimmune Diabetes

2005 • 76 citations

Anergy and not Clonal Ignorance Determines the Fate of B Cells that Recognize a Physiological Autoantigen

2001 • 75 citations

Autoantigen-Specific B Cell Activation in FAS-Deficient Rheumatoid Factor Immunoglobulin Transgenic Mice

1999 • 74 citations

Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1

2002 • 70 citations

Loss of the proapoptotic protein, Bim, breaks B cell anergy

2006 • 68 citations

Characterization of anti-single-stranded DNA B cells in a non-autoimmune background.

1997 • 67 citations

Cutting Edge: Transitional T3 B Cells Do Not Give Rise to Mature B Cells, Have Undergone Selection, and Are Reduced in Murine Lupus

2007 • 64 citations

Tolerant B Lymphocytes Acquire Resistance to Fas-mediated Apoptosis after Treatment with Interleukin 4 but Not after Treatment with Specific Antigen Unless a Surface Immunoglobulin Threshold Is Exceeded

1998 • 61 citations

Chronic Graft-Versus-Host in Ig Knockin Transgenic Mice Abrogates B Cell Tolerance in Anti-Double-Stranded DNA B Cells

2002 • 59 citations

Functional Consequences of the Developmental Arrest and Follicular Exclusion of Anti-Double-Stranded DNA B Cells

2000 • 57 citations

Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice.

1993 • 57 citations

Persistence of functionally compromised anti-double-stranded DNA B cells in the periphery of non-autoimmune mice

1997 • 53 citations

Correlation of 9G4 idiotope with disease activity in patients with systemic lupus erythematosus

1998 • 51 citations

B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation.

1997 • 46 citations

Rescue of self-reactive B cells by provision of T cell helpin vivo

1998 • 43 citations

Induction of Autoimmunity in a Transgenic Model of B Cell Receptor Peripheral Tolerance: Changes in Coreceptors and B Cell Receptor-Induced Tyrosine-Phosphoproteins

1999 • 43 citations

Cutting Edge: Low-Affinity, Smith Antigen-Specific B Cells Are Tolerized by Dendritic Cells and Macrophages

2005 • 43 citations

VH and VL gene usage by murine IgG antibodies that bind autologous insulin.

1990 • 42 citations

Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6

2007 • 41 citations

Transmodulation of BCR Signaling by Transduction- Incompetent Antigen Receptors: Implications for Impaired Signaling in Anergic B Cells

2002 • 40 citations

Clonal Silencing of Self-reactive B Lymphocytes in a Transgenic Mouse Model

1989 • 36 citations

Immunological and Pathological Consequences of Mutations in both Fas and Fas Ligand

1998 • 33 citations

Cutting Edge: Acute and Chronic Exposure of Immature B Cells to Antigen Leads to Impaired Homing and SHIP1-Dependent Reduction in Stromal Cell-Derived Factor-1 Responsiveness

2007 • 33 citations

Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance

2006 • 31 citations

Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.

1995 • 29 citations

Activation of Rheumatoid Factor (RF) B Cells and Somatic Hypermutation Outside of Germinal Centers in Autoimmune‐Prone MRL/lpr Mice

2003 • 22 citations

Impaired Intracellular Calcium Mobilization and NFATc1 Availability in Tolerant Anti-Insulin B Cells

2006 • 20 citations

Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion

2007 • 19 citations

Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6

2007 • 9 citations